ZNF93: Zinc Finger Protein 93
A KRAB-ZFP transcriptional repressor involved in retrotransposon silencing and genomic stability.
Gene Information Card
| Symbol | ZNF93 |
|---|---|
| Full Name | zinc finger protein 93 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p12 |
| NCBI Gene ID | 81931 ncbi.nlm.nih.gov/gene/81931 |
| Ensembl ID | ENSG00000104884 |
| UniProt ID | Q6P1N0 |
| OMIM ID | 604752 |
| HGNC ID | 13138 |
| Aliases | ZNF505, ZNF93L, ZNF93S |
Description
ZNF93 (zinc finger protein 93) is a member of the Krüppel-associated box (KRAB) zinc finger protein family. It functions as a transcriptional repressor by recruiting chromatin-modifying complexes to specific DNA sequences. ZNF93 is involved in silencing endogenous retrotransposons, particularly LINE-1 elements, thereby contributing to genomic stability. The gene is located on chromosome 19p12 within a cluster of KRAB-ZFP genes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Dysregulation of ZNF93 may alter retrotransposon silencing, leading to genomic instability and oncogenesis. | COSMIC; literature review |
| Neurodevelopmental disorders | Potential role via transcriptional repression of target genes; limited direct evidence. | ClinVar; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | RNA-seq data |
| K562 | 7.8 | RNA-seq data |
| HeLa | 6.5 | RNA-seq data |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.01% | Unknown functional impact |
| c.1456G>A (p.Gly486Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • zinc ion binding |
| • regulation of transcription by RNA polymerase II | • negative regulation of transcription |
| • chromatin binding |
Pathways
• Retrotransposon silencing
• KRAB-ZFP mediated repression
Protein Summary
ZNF93 encodes a KRAB domain-containing zinc finger protein. The KRAB domain mediates interaction with KAP1 (TRIM28), recruiting histone methyltransferases and deacetylases to repress transcription. The C-terminal zinc finger array binds specific DNA sequences, including those derived from retrotransposons. ZNF93 is primarily nuclear and contributes to epigenetic silencing of LINE-1 elements.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF93 Knockout HEK293 Cell Line | EDJ-KQ9781 | Human | 81931 | Details Get a Quote |
| ZNF93 Knockout HeLa Cell Line | EDJ-KQ57429 | Human | 81931 | Details Get a Quote |
| ZNF93 Knockout A-549 Cell Line | EDJ-KQ65934 | Human | 81931 | Details Get a Quote |
| ZNF93 Knockout HCT 116 Cell Line | EDJ-KQ74360 | Human | 81931 | Details Get a Quote |
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