ZNF880: Zinc Finger Protein 880
A KRAB-Zinc Finger Transcription Factor with Limited Functional Annotation
Gene Information Card
| Symbol | ZNF880 |
|---|---|
| Full Name | Zinc Finger Protein 880 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 84726 ncbi.nlm.nih.gov/gene/84726 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | Q6P9G4 |
| OMIM ID | 618446 |
| HGNC ID | 28377 |
| Aliases | FLJ32942, ZNF880 |
Description
ZNF880 encodes a zinc finger protein of the Krüppel-associated box (KRAB) subfamily. The protein contains a KRAB domain at the N-terminus and multiple C2H2-type zinc finger motifs, suggesting a role in transcriptional regulation via DNA binding and chromatin remodeling. Its specific biological functions and target genes remain largely uncharacterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.1 | Low |
| Adrenal gland | 2.8 | Low |
| Brain | 1.5 | Not detected |
| Liver | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.5 | Low expression |
| K562 | 3.0 | Low expression |
| HeLa | 2.1 | Low expression |
| HepG2 | 1.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No functional studies available
Gain of Function (GOF)
No functional studies available
Dominant Negative (DN)
No functional studies available
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978) |
| • nucleus (GO:0005634) | • metal ion binding (GO:0046872) |
Protein Summary
ZNF880 is a 597-amino acid protein containing a KRAB domain and 14 C2H2-type zinc fingers. It is predicted to localize to the nucleus and function as a sequence-specific DNA-binding transcription repressor. No protein structure or post-translational modifications have been experimentally characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF880 Knockout HEK293 Cell Line | EDJ-KQ11581 | Human | 400713 | Details Get a Quote |
| ZNF880 Knockout HeLa Cell Line | EDJ-KQ60271 | Human | 400713 | Details Get a Quote |
| ZNF880 Knockout A-549 Cell Line | EDJ-KQ68734 | Human | 400713 | Details Get a Quote |
| ZNF880 Knockout HCT 116 Cell Line | EDJ-KQ77101 | Human | 400713 | Details Get a Quote |
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