ZNF845: Zinc Finger Protein 845
A Krüppel-associated box (KRAB) domain-containing zinc finger protein with potential roles in transcriptional regulation and cancer.
Gene Information Card
| Symbol | ZNF845 |
|---|---|
| Full Name | zinc finger protein 845 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 283554 ncbi.nlm.nih.gov/gene/283554 |
| Ensembl ID | ENSG00000188629 |
| UniProt ID | Q5VWF2 |
| OMIM ID | 618412 |
| HGNC ID | 28087 |
| Aliases | FLJ45831, MGC138499 |
Description
ZNF845 (zinc finger protein 845) is a protein-coding gene located on chromosome 19q13.43. It encodes a member of the Krüppel C2H2-type zinc finger protein family, characterized by an N-terminal KRAB (Krüppel-associated box) domain and multiple C2H2 zinc finger motifs. The protein is predicted to function as a transcriptional repressor through recruitment of chromatin-modifying complexes. ZNF845 is expressed in various tissues and has been implicated in cancer through somatic mutations and altered expression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Somatic mutations in ZNF845 may alter transcriptional repression of target genes, contributing to tumorigenesis. | COSMIC; literature |
| Breast cancer | ZNF845 expression changes observed; potential role in proliferation. | COSMIC; literature |
| Lung cancer | Somatic missense mutations reported in lung adenocarcinoma. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Breast | 5.3 | Low |
| Colon | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Embryonic kidney; moderate expression |
| HeLa | 7.8 | Cervical cancer; moderate expression |
| A549 | 6.5 | Lung cancer; low expression |
| MCF7 | 5.9 | Breast cancer; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123G>A (p.Gly375Arg) | Missense | <0.1% | Unknown; predicted damaging |
| c.1456C>T (p.Arg486Trp) | Missense | <0.1% | Unknown; predicted damaging |
| c.1789_1790insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1789_1790insA) likely result in truncated protein and loss of DNA-binding or repressor function.
Gain of Function (GOF)
No evidence of gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• No specific pathways curated in Reactome or KEGG for ZNF845.
Protein Summary
ZNF845 is a 646-amino acid protein containing an N-terminal KRAB domain and 12 C2H2-type zinc finger motifs. The KRAB domain mediates interaction with KAP1/TRIM28, recruiting histone methyltransferases and deacetylases to repress transcription. The zinc finger array is predicted to bind specific DNA sequences, targeting the repressor complex to promoters. The protein is localized to the nucleus and is expressed in multiple tissues, with highest levels in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF845 Knockout HEK293 Cell Line | EDJ-KQ10771 | Human | 91664 | Details Get a Quote |
| ZNF845 Knockout A-549 Cell Line | EDJ-KQ38383 | Human | 91664 | Details Get a Quote |
| ZNF845 Knockout HCT 116 Cell Line | EDJ-KQ38384 | Human | 91664 | Details Get a Quote |
| ZNF845 Knockout HeLa Cell Line | EDJ-KQ38385 | Human | 91664 | Details Get a Quote |
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