ZNF844
Zinc Finger Protein 844: A KRAB-ZFP Family Member with Potential Roles in Transcriptional Regulation
Gene Information Card
| Symbol | ZNF844 |
|---|---|
| Full Name | Zinc Finger Protein 844 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 284382 ncbi.nlm.nih.gov/gene/284382 |
| Ensembl ID | ENSG00000188313 |
| UniProt ID | Q5VU65 |
| OMIM ID | 618384 |
| HGNC ID | 33107 |
| Aliases | FLJ45831, MGC119751, MGC119752 |
Description
ZNF844 encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) zinc finger protein family. These proteins typically function as transcriptional repressors by recruiting chromatin-modifying complexes. ZNF844 is located on chromosome 19q13.43 and is expressed in various tissues. Its specific biological roles are not fully characterized, but it is predicted to be involved in transcriptional regulation and may play a role in development and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations confirmed | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 3.2 | Low |
| Thyroid | 2.1 | Low |
| Prostate | 1.8 | Low |
| Adrenal gland | 1.5 | Low |
| Brain | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 2.5 | Low expression |
| K562 | 1.9 | Low expression |
| HeLa | 1.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants curated | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • Zinc ion binding (GO:0008270) |
| • Nucleus (GO:0005634) | • Regulation of transcription by RNA polymerase II (GO:0006357) |
Protein Summary
ZNF844 is a 522-amino acid protein containing multiple C2H2-type zinc finger domains and a KRAB domain at its N-terminus. The KRAB domain mediates interaction with KAP1/TRIM28, leading to histone modification and transcriptional repression. The protein is predicted to localize to the nucleus and bind DNA in a sequence-specific manner. Its exact target genes and physiological functions remain to be elucidated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF844 Knockout HEK293 Cell Line | EDJ-KQ15660 | Human | 284391 | Details Get a Quote |
| ZNF844 Knockout HeLa Cell Line | EDJ-KQ59463 | Human | 284391 | Details Get a Quote |
| ZNF844 Knockout A-549 Cell Line | EDJ-KQ67927 | Human | 284391 | Details Get a Quote |
| ZNF844 Knockout HCT 116 Cell Line | EDJ-KQ76306 | Human | 284391 | Details Get a Quote |
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