ZNF843
Zinc Finger Protein 843: A KRAB-ZFP Family Member with Limited Functional Annotation
Gene Information Card
| Symbol | ZNF843 |
|---|---|
| Full Name | zinc finger protein 843 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p11.2 |
| NCBI Gene ID | 100130894 ncbi.nlm.nih.gov/gene/100130894 |
| Ensembl ID | ENSG00000204536 |
| UniProt ID | A6NJT5 |
| OMIM ID | - |
| HGNC ID | 37236 |
| Aliases | FLJ39660, MGC26717 |
Description
ZNF843 encodes a zinc finger protein 843, a member of the Krüppel-associated box (KRAB) zinc finger protein family. These proteins typically function as transcriptional repressors via recruitment of chromatin-modifying complexes. The specific biological role of ZNF843 remains incompletely characterized, but it is predicted to be involved in transcriptional regulation. The gene is located on chromosome 16p11.2, a region associated with neurodevelopmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.7 | Low |
| Brain (cerebellum) | 1.5 | Low |
| Thyroid | 1.2 | Low |
| Adipose tissue | 0.9 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 1.8 | Low expression |
| K562 | 0.6 | Not detected |
| HeLa | 0.4 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | - | - | - |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • nucleic acid binding (GO:0003676) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • metal ion binding (GO:0046872) |
Protein Summary
ZNF843 is a 504-amino acid protein containing multiple C2H2-type zinc finger domains and an N-terminal KRAB domain. It is predicted to localize to the nucleus and bind DNA, likely acting as a transcriptional repressor. No functional studies have been published, and its physiological targets remain unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF843 Knockout HEK293 Cell Line | EDJ-KQ16383 | Human | 283933 | Details Get a Quote |
| ZNF843 Knockout HeLa Cell Line | EDJ-KQ59419 | Human | 283933 | Details Get a Quote |
| ZNF843 Knockout A-549 Cell Line | EDJ-KQ67886 | Human | 283933 | Details Get a Quote |
| ZNF843 Knockout HCT 116 Cell Line | EDJ-KQ76266 | Human | 283933 | Details Get a Quote |
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