ZNF841 Gene: Zinc Finger Protein 841 – Structure, Function, and Clinical Relevance
Comprehensive overview of ZNF841, a KRAB zinc finger protein, including genomic context, expression, and disease associations.
Gene Information Card
| Symbol | ZNF841 |
|---|---|
| Full Name | zinc finger protein 841 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.12 (GRCh38) |
| NCBI Gene ID | 123920 ncbi.nlm.nih.gov/gene/123920 |
| Ensembl ID | ENSG00000160193 |
| UniProt ID | Q8N1W0 |
| OMIM ID | Not available (no OMIM entry) |
| HGNC ID | 28009 |
| Aliases | FLJ45850, MGC138156 |
Description
ZNF841 encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) domain-containing family. It is predicted to function as a transcription factor involved in transcriptional regulation, likely through DNA binding and chromatin remodeling. The protein contains multiple C2H2-type zinc finger domains and a KRAB domain, which is characteristic of proteins that recruit co-repressor complexes. ZNF841 is located on chromosome 19q13.12, a region rich in zinc finger genes. Its precise biological role remains under investigation, but it is implicated in cellular processes such as differentiation and proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (pan-cancer) | Potential dysregulation in tumorigenesis; altered expression may affect transcriptional networks. | COSMIC: somatic mutations and copy number alterations observed in various cancers. |
| Neurodevelopmental disorders | Possible involvement due to zinc finger protein family roles in neural development; not yet confirmed. | ClinVar: no pathogenic variants reported; limited evidence. |
| Immunodeficiency | KRAB-ZNF proteins modulate immune gene expression; ZNF841 may contribute, but no direct evidence. | No direct clinical association in ClinVar or OMIM. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Thyroid | 8.5 | Low |
| Adrenal gland | 7.2 | Low |
| Bone marrow | 6.8 | Low |
| Lung | 5.9 | Low |
| Brain | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 10.2 | Moderate expression |
| HeLa (cervical cancer) | 7.5 | Low expression |
| A549 (lung cancer) | 6.1 | Low expression |
| HepG2 (liver cancer) | 5.4 | Low expression |
| MCF7 (breast cancer) | 4.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | 0.01% (gnomAD) | Unknown; predicted possibly damaging by in silico tools. |
| c.567_568insA (p.Glu190fs) | Frameshift | Rare | Predicted loss-of-function; may lead to nonsense-mediated decay. |
| c.789G>A (p.Val263Ile) | Missense | 0.03% | Benign; no clinical significance. |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants likely result in loss of protein function, potentially affecting transcriptional regulation.
Gain of Function (GOF)
No evidence of gain-of-function mutations; not reported in literature.
Dominant Negative (DN)
No evidence; not described.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • Zinc ion binding (GO:0008270) |
| • Regulation of transcription by RNA polymerase II (GO:0006357) | • Nucleus (GO:0005634) |
Pathways
• No specific pathways curated in Reactome or KEGG for ZNF841; likely involved in generic transcriptional regulation.
Protein Summary
ZNF841 is a KRAB zinc finger protein of 548 amino acids, containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. It is localized to the nucleus and binds DNA via zinc fingers, potentially repressing or activating gene expression. The protein is expressed at low to moderate levels across tissues, with highest in testis. Its function is not fully characterized, but it may play roles in development and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF841 Knockout HEK293 Cell Line | EDJ-KQ16382 | Human | 284371 | Details Get a Quote |
| ZNF841 Knockout A-549 Cell Line | EDJ-KQ50010 | Human | 284371 | Details Get a Quote |
| ZNF841 Knockout HeLa Cell Line | EDJ-KQ50011 | Human | 284371 | Details Get a Quote |
| ZNF841 Knockout HCT 116 Cell Line | EDJ-KQ76302 | Human | 284371 | Details Get a Quote |
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