ZNF835 Gene: Function, Expression, and Disease Associations

ZNF835 is a protein-coding gene that encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. These proteins typically function as transcription factors, regulating gene expression by binding to specific DNA sequences. ZNF835 is located on chromosome 19q13.43, a region known for a cluster of zinc finger genes. The protein contains multiple C2H2-type zinc finger domains and a KRAB domain, suggesting a role in transcriptional repression. While its specific target genes and biological functions are not fully characterized, ZNF835 has been implicated in various cellular processes, including cell proliferation and differentiation, and its dysregulation has been observed in certain cancers.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways have been curated for ZNF835 in major databases.

ZNF835 is a KRAB domain-containing zinc finger protein. The KRAB domain is often involved in recruiting co-repressor complexes, leading to transcriptional repression. The protein contains multiple C2H2-type zinc finger motifs that mediate sequence-specific DNA binding. Although the exact target genes are unknown, ZNF835 likely regulates the expression of genes involved in development, differentiation, or cell cycle control. Its expression is relatively low in most tissues, with highest levels in testis. Further research is needed to fully elucidate its biological functions and potential role in disease.