ZNF831
Zinc Finger Protein 831
Gene Information Card
| Symbol | ZNF831 |
|---|---|
| Full Name | zinc finger protein 831 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.32 |
| NCBI Gene ID | 100128731 ncbi.nlm.nih.gov/gene/100128731 |
| Ensembl ID | ENSG00000196419 |
| UniProt ID | Q5VWG9 |
| OMIM ID | 618215 |
| HGNC ID | 28000 |
| Aliases | FLJ45831, MGC16384 |
Description
ZNF831 is a protein-coding gene that encodes a zinc finger protein of the Krüppel-associated box (KRAB) domain family. It is predicted to function as a transcription regulator involved in DNA-binding and transcriptional repression. The gene is located on chromosome 20q13.32 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Low |
| Spleen | 6.5 | Low |
| Lung | 5.1 | Low |
| Brain | 3.8 | Not detected |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.3 | Low expression |
| K562 | 3.1 | Low expression |
| HeLa | 2.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants curated | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • metal ion binding (GO:0046872) |
| • nucleus (GO:0005634) |
Protein Summary
ZNF831 is a zinc finger protein containing a KRAB domain, suggesting a role in transcriptional repression. The protein is localized to the nucleus and binds DNA via its zinc finger motifs. Its specific biological functions and interaction partners remain largely uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF831 Knockout HEK293 Cell Line | EDJ-KQ8419 | Human | 128611 | Details Get a Quote |
| ZNF831 Knockout HeLa Cell Line | EDJ-KQ58244 | Human | 128611 | Details Get a Quote |
| ZNF831 Knockout A-549 Cell Line | EDJ-KQ66732 | Human | 128611 | Details Get a Quote |
| ZNF831 Knockout HCT 116 Cell Line | EDJ-KQ75143 | Human | 128611 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
