ZNF816-ZNF321P: A Readthrough Fusion Gene with Limited Functional Annotation
A naturally occurring readthrough transcript combining zinc finger protein 816 and zinc finger protein 321 pseudogene, with no established disease association or clinical significance.
Gene Information Card
| Symbol | ZNF816-ZNF321P |
|---|---|
| Full Name | ZNF816-ZNF321P readthrough (NMD candidate) |
| Gene Type | Readthrough transcript (protein-coding, NMD candidate) |
| Chromosomal Location | 19q13.41 (GRCh38) |
| NCBI Gene ID | 100861540 ncbi.nlm.nih.gov/gene/100861540 |
| Ensembl ID | ENSG00000273176 |
| UniProt ID | None (no protein product annotated) |
| OMIM ID | None |
| HGNC ID | 44174 |
| Aliases | ZNF816-ZNF321P |
Description
ZNF816-ZNF321P is a readthrough gene locus on chromosome 19q13.41, formed by the natural fusion of the ZNF816 (zinc finger protein 816) gene and the ZNF321P pseudogene. This readthrough transcript is predicted to be a candidate for nonsense-mediated decay (NMD), meaning it may not produce a stable protein product. The gene is annotated in NCBI and Ensembl, but lacks extensive functional characterization. No disease associations or clinical significance have been reported.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No known disease association | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| No tissue expression data available | Not reported | Not reported |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No cell line expression data available | Not reported | Not reported |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No clinically significant variants reported | Not applicable | Not reported | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No functional data available; readthrough transcript likely subject to NMD, so loss-of-function effects are not characterized.
Gain of Function (GOF)
No evidence of gain-of-function activity.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Protein Summary
No protein product has been annotated for ZNF816-ZNF321P. The readthrough transcript is predicted to undergo nonsense-mediated decay, and no UniProt entry exists. Therefore, no functional protein summary can be provided.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF816-ZNF321P Knockout HEK293 Cell Line | EDJ-KQ52496 | Human | 100529240 | Details Get a Quote |
| ZNF816-ZNF321P Knockout HeLa Cell Line | EDJ-KQ60959 | Human | 100529240 | Details Get a Quote |
| ZNF816-ZNF321P Knockout A-549 Cell Line | EDJ-KQ69434 | Human | 100529240 | Details Get a Quote |
| ZNF816-ZNF321P Knockout HCT 116 Cell Line | EDJ-KQ77785 | Human | 100529240 | Details Get a Quote |
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