ZNF805 Gene: Zinc Finger Protein 805 | Function, Expression & Disease

ZNF805 (zinc finger protein 805) is a protein-coding gene located on chromosome 19q13.12. It encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, which are involved in transcriptional regulation. The protein contains multiple C2H2-type zinc finger domains, suggesting a role in DNA binding and gene expression control. ZNF805 is expressed in various tissues, with notable levels in the testis and brain. Its exact biological function is not fully characterized, but it is implicated in transcriptional regulation and potentially in developmental processes. No OMIM entry is available, indicating limited clinical characterization.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways curated for ZNF805 in major databases. As a KRAB-ZFP

• it may be involved in transcriptional repression pathways.

ZNF805 is a zinc finger protein of the KRAB-ZFP family, characterized by an N-terminal KRAB domain and multiple C2H2 zinc finger motifs. It is predicted to bind DNA and regulate transcription, likely acting as a transcriptional repressor. The protein is localized to the nucleus. Its expression is highest in testis and brain, suggesting a role in spermatogenesis or neuronal function. However, functional studies are lacking, and its physiological substrates and target genes remain unknown. No disease association has been established, and it is not currently a focus of clinical research.