ZNF80 Gene - Zinc Finger Protein 80 | Function, Expression & Disease

ZNF80 (zinc finger protein 80) is a protein-coding gene located on chromosome 3p12.3. It encodes a Krüppel-associated box (KRAB) domain-containing zinc finger protein, which functions as a transcriptional repressor. The protein contains multiple C2H2-type zinc finger motifs and is involved in regulating gene expression, potentially through chromatin remodeling and recruitment of co-repressor complexes. ZNF80 is part of the large family of KRAB zinc finger proteins, many of which are involved in development, differentiation, and disease.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways curated in Reactome or KEGG for ZNF80.

ZNF80 encodes a 482-amino acid protein (UniProt P51505) containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. The KRAB domain mediates transcriptional repression through interaction with KAP1/TRIM28, recruiting histone deacetylases and methyltransferases. The zinc fingers enable sequence-specific DNA binding. ZNF80 is predominantly nuclear and likely regulates genes involved in cell differentiation and development.