ZNF799 Gene: Function, Expression, and Disease Associations | Biomedical Database

ZNF799 is a protein-coding gene located on chromosome 19q13.12. It encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. These proteins typically function as transcription factors, often involved in transcriptional regulation, chromatin remodeling, and protein-protein interactions. ZNF799 is predicted to be involved in DNA-binding transcription factor activity and regulation of gene expression. The gene is expressed in various tissues, with notable expression in the testis and some brain regions. While its specific biological roles are not fully characterized, it is part of a large family of KRAB-ZNFs that play roles in development, differentiation, and disease, including cancer.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways are curated for ZNF799 in major databases.

ZNF799 encodes a 548-amino acid protein with multiple C2H2-type zinc finger domains and a KRAB domain at the N-terminus. The KRAB domain is known to mediate transcriptional repression via recruitment of co-repressors such as KAP1. The protein is predicted to localize to the nucleus and bind DNA. Its exact target genes are unknown, but it likely regulates gene expression in a tissue-specific manner. Structural predictions suggest a typical KRAB-ZNF architecture, with the zinc finger array mediating sequence-specific DNA binding.