ZNF793
Zinc Finger Protein 793: A KRAB-ZFP Transcriptional Regulator
Gene Information Card
| Symbol | ZNF793 |
|---|---|
| Full Name | zinc finger protein 793 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 163050 ncbi.nlm.nih.gov/gene/163050 |
| Ensembl ID | ENSG00000188283 |
| UniProt ID | Q8N6T7 |
| OMIM ID | 618412 |
| HGNC ID | 28004 |
| Aliases | FLJ32709, ZNF793L |
Description
ZNF793 encodes a zinc finger protein of the Krüppel-associated box (KRAB) domain-containing family. These proteins typically function as transcriptional repressors by recruiting chromatin-modifying complexes to specific genomic loci. ZNF793 is located on chromosome 19q13.43 and is expressed in various tissues, with highest levels in testis and brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association established | Not determined | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 4.1 | Low |
| Liver | 2.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 6.8 | Low expression |
| K562 | 3.5 | Not detected |
| HeLa | 5.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA binding (GO:0003677) | • RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978) |
| • nucleus (GO:0005634) | • metal ion binding (GO:0046872) |
Protein Summary
ZNF793 is a 613-amino acid protein containing 14 C2H2-type zinc finger domains and an N-terminal KRAB domain. It is predicted to localize to the nucleus and bind DNA, likely functioning as a sequence-specific transcriptional repressor. The protein is conserved in primates and rodents.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF793 Knockout HEK293 Cell Line | EDJ-KQ16375 | Human | 390927 | Details Get a Quote |
| ZNF793 Knockout HeLa Cell Line | EDJ-KQ60197 | Human | 390927 | Details Get a Quote |
| ZNF793 Knockout A-549 Cell Line | EDJ-KQ68659 | Human | 390927 | Details Get a Quote |
| ZNF793 Knockout HCT 116 Cell Line | EDJ-KQ77026 | Human | 390927 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
