ZNF792: Zinc Finger Protein 792
A KRAB domain-containing zinc finger protein with potential roles in transcriptional regulation and cancer.
Gene Information Card
| Symbol | ZNF792 |
|---|---|
| Full Name | zinc finger protein 792 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 126961 ncbi.nlm.nih.gov/gene/126961 |
| Ensembl ID | ENSG00000188385 |
| UniProt ID | Q3KNS6 |
| OMIM ID | 618940 |
| HGNC ID | 26422 |
| Aliases | FLJ32743, MGC26733 |
Description
ZNF792 encodes a zinc finger protein containing a KRAB (Krüppel-associated box) domain at the N-terminus and multiple C2H2-type zinc finger motifs. KRAB domain-containing proteins typically function as transcriptional repressors via recruitment of chromatin-modifying complexes. ZNF792 is expressed in various tissues and may be involved in cell proliferation and differentiation. Its precise biological functions remain under investigation, but alterations in expression have been noted in certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential dysregulation of ZNF792 expression may contribute to tumorigenesis; exact mechanism unclear. | Expression profiling studies (e.g., TCGA) show altered ZNF792 levels in breast cancer samples. |
| Colorectal cancer | ZNF792 may act as a transcriptional repressor affecting cell cycle genes; overexpression observed in some colorectal tumors. | Gene expression microarray data (GEO) and COSMIC mutation reports. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.3 | Medium |
| Prostate | 7.1 | Medium |
| Lung | 5.6 | Low |
| Breast | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Embryonic kidney; moderate expression |
| HeLa | 6.8 | Cervical carcinoma; low expression |
| MCF7 | 5.3 | Breast cancer; low expression |
| HepG2 | 4.9 | Hepatocellular carcinoma; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Ile) | Missense | <0.1% | Unknown; located in KRAB domain, may affect protein-protein interactions |
| c.457G>A (p.Gly153Arg) | Missense | <0.1% | Unknown; within zinc finger region, may alter DNA binding |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• No specific pathways curated in Reactome or KEGG for ZNF792.
Protein Summary
ZNF792 is a 548-amino acid protein with a KRAB domain (residues 1–75) and 12 C2H2-type zinc finger domains (residues 130–548). The KRAB domain mediates transcriptional repression through interaction with KAP1/TRIM28 and recruitment of histone modifiers. The zinc fingers are predicted to bind specific DNA sequences, suggesting ZNF792 functions as a sequence-specific transcriptional repressor. Structural studies are limited.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF792 Knockout HEK293 Cell Line | EDJ-KQ8907 | Human | 126375 | Details Get a Quote |
| ZNF792 Knockout HCT 116 Cell Line | EDJ-KQ34017 | Human | 126375 | Details Get a Quote |
| ZNF792 Knockout A-549 Cell Line | EDJ-KQ35250 | Human | 126375 | Details Get a Quote |
| ZNF792 Knockout HeLa Cell Line | EDJ-KQ35251 | Human | 126375 | Details Get a Quote |
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