ZNF791: Zinc Finger Protein 791
A KRAB-Zinc Finger Transcription Factor with Emerging Roles in Gene Regulation
Gene Information Card
| Symbol | ZNF791 |
|---|---|
| Full Name | zinc finger protein 791 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.12 |
| NCBI Gene ID | 163049 ncbi.nlm.nih.gov/gene/163049 |
| Ensembl ID | ENSG00000173875 |
| UniProt ID | Q9P2L1 |
| OMIM ID | 618447 |
| HGNC ID | 25999 |
| Aliases | FLJ32709, MGC138290 |
Description
ZNF791 encodes a zinc finger protein of the Krüppel-associated box (KRAB) subfamily. The protein contains a KRAB domain at the N-terminus and multiple C2H2-type zinc finger motifs, characteristic of transcriptional repressors that recruit chromatin-modifying complexes. ZNF791 is involved in transcriptional regulation and may play roles in development and cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Moderate expression |
| HeLa | 7.8 | Low expression |
| K562 | 5.4 | Low expression |
| HepG2 | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • regulation of transcription by RNA polymerase II (GO:0006357) |
Pathways
• No curated pathways available
Protein Summary
ZNF791 is a 569-amino acid protein with a KRAB domain (residues 2-75) and 12 C2H2-type zinc finger domains (residues 155-179, 207-231, 235-259, 263-287, 291-315, 319-343, 347-371, 375-399, 403-427, 431-455, 459-483, 487-511). The KRAB domain mediates interaction with KAP1/TRIM28 to repress transcription via histone modification. The zinc fingers are predicted to bind specific DNA sequences. Subcellular localization is nuclear.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF791 Knockout HEK293 Cell Line | EDJ-KQ16374 | Human | 163049 | Details Get a Quote |
| ZNF791 Knockout A-549 Cell Line | EDJ-KQ49991 | Human | 163049 | Details Get a Quote |
| ZNF791 Knockout HCT 116 Cell Line | EDJ-KQ49992 | Human | 163049 | Details Get a Quote |
| ZNF791 Knockout HeLa Cell Line | EDJ-KQ49993 | Human | 163049 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
