ZNF790 Gene - Zinc Finger Protein 790: Function, Expression, and Clinical Significance

ZNF790 encodes a zinc finger protein of the Krüppel-associated box (KRAB) family, characterized by an N-terminal KRAB domain and multiple C2H2-type zinc finger motifs. As a transcription factor, it likely represses gene expression via recruitment of chromatin-modifying complexes. The gene is located on chromosome 19q13.43, a region associated with various genomic disorders. Expression data suggest broad tissue distribution with highest levels in testis and brain. Limited functional studies indicate potential roles in development and cellular differentiation.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No curated pathways in Reactome or KEGG

ZNF790 is a 598-amino acid protein containing a KRAB domain (residues 1–75) and 12 C2H2-type zinc finger domains (residues 100–580). The KRAB domain mediates transcriptional repression through interaction with KAP1/TRIM28, recruiting histone deacetylases and methyltransferases. The zinc fingers are predicted to bind specific DNA sequences, though target genes remain unidentified. Structural modeling suggests a compact conformation with zinc fingers arranged in a helical array. Post-translational modifications include phosphorylation sites (Ser/Thr) and potential ubiquitination, but experimental validation is lacking.