ZNF79 Gene - Zinc Finger Protein 79
A KRAB-Zinc Finger Transcription Factor with Potential Roles in Gene Regulation and Disease
Gene Information Card
| Symbol | ZNF79 |
|---|---|
| Full Name | Zinc Finger Protein 79 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q33.2 |
| NCBI Gene ID | 7627 ncbi.nlm.nih.gov/gene/7627 |
| Ensembl ID | ENSG00000196152 |
| UniProt ID | Q15937 |
| OMIM ID | 194552 |
| HGNC ID | 13151 |
| Aliases | pT1, ZNF-pT1 |
Description
ZNF79 encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) domain-containing family of transcription factors. The protein contains multiple C2H2-type zinc finger domains and a KRAB domain, suggesting a role in transcriptional regulation. ZNF79 is localized to the nucleus and may be involved in chromatin remodeling and gene silencing. Its expression is widespread but varies across tissues, and it has been implicated in several cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression; potential role in tumor suppression or oncogenesis | COSMIC: mutations and expression changes in multiple cancer types |
| Neurodevelopmental disorders | Potential involvement in neuronal gene regulation | Limited evidence; inferred from KRAB-ZNF family function |
| Immunodeficiency | Possible role in immune cell development | Not directly documented; speculative based on expression in immune tissues |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Thyroid | 10.1 | Medium |
| Adrenal gland | 8.5 | Low |
| Bone marrow | 7.2 | Low |
| Lung | 6.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.2 | Leukemia cell line; high expression |
| HeLa | 8.4 | Cervical cancer; moderate |
| A549 | 6.1 | Lung carcinoma; low |
| HepG2 | 5.3 | Liver cancer; low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1000C>T (p.Arg334Ter) | Nonsense | 0.01% (gnomAD) | Truncated protein; likely loss of function |
| c.1500A>G (p.Ile500Met) | Missense | 0.05% (gnomAD) | Unknown; may affect zinc finger binding |
| c.2000delA (p.Lys667ArgfsTer23) | Frameshift | 0.001% (COSMIC) | Loss of function; observed in cancer samples |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations leading to premature stop codons are predicted to cause loss of function via nonsense-mediated decay or truncated protein lacking DNA-binding domains.
Gain of Function (GOF)
No evidence for gain-of-function mutations; ZNF79 is not a known oncogene.
Dominant Negative (DN)
No evidence; KRAB-ZNF proteins typically act as monomers, and dominant-negative effects are not documented.
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • zinc ion binding |
| • transcription regulation | • nucleus |
| • chromatin binding |
Pathways
• No specific pathway curated in major databases; likely involved in transcriptional repression via KRAB domain interaction with KAP1.
Protein Summary
ZNF79 is a 673-amino acid protein with a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. It is predicted to bind DNA and regulate gene expression. The KRAB domain mediates interaction with KAP1 (TRIM28), recruiting histone methyltransferases to silence target genes. ZNF79 is expressed in various tissues, with highest levels in testis and thyroid. Its exact biological role remains under investigation, but it may contribute to cellular differentiation and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF79 Knockout HEK293 Cell Line | EDJ-KQ5344 | Human | 7633 | Details Get a Quote |
| ZNF792 Knockout HEK293 Cell Line | EDJ-KQ8907 | Human | 126375 | Details Get a Quote |
| ZNF799 Knockout HEK293 Cell Line | EDJ-KQ10616 | Human | 90576 | Details Get a Quote |
| ZNF790 Knockout HEK293 Cell Line | EDJ-KQ16373 | Human | 388536 | Details Get a Quote |
| ZNF791 Knockout HEK293 Cell Line | EDJ-KQ16374 | Human | 163049 | Details Get a Quote |
| ZNF793 Knockout HEK293 Cell Line | EDJ-KQ16375 | Human | 390927 | Details Get a Quote |
| ZNF792 Knockout HCT 116 Cell Line | EDJ-KQ34017 | Human | 126375 | Details Get a Quote |
| ZNF799 Knockout A-549 Cell Line | EDJ-KQ38111 | Human | 90576 | Details Get a Quote |
| ZNF799 Knockout HeLa Cell Line | EDJ-KQ38112 | Human | 90576 | Details Get a Quote |
| ZNF791 Knockout A-549 Cell Line | EDJ-KQ49991 | Human | 163049 | Details Get a Quote |
| ZNF791 Knockout HCT 116 Cell Line | EDJ-KQ49992 | Human | 163049 | Details Get a Quote |
| ZNF791 Knockout HeLa Cell Line | EDJ-KQ49993 | Human | 163049 | Details Get a Quote |
| ZNF79 Knockout A-549 Cell Line | EDJ-KQ29740 | Human | 7633 | Details Get a Quote |
| ZNF79 Knockout HCT 116 Cell Line | EDJ-KQ29741 | Human | 7633 | Details Get a Quote |
| ZNF79 Knockout HeLa Cell Line | EDJ-KQ29742 | Human | 7633 | Details Get a Quote |
Displaying Records 1 To 15 Of 24 Records
