ZNF787
Zinc Finger Protein 787: A Transcriptional Regulator with Emerging Roles in Cancer and Development
Gene Information Card
| Symbol | ZNF787 |
|---|---|
| Full Name | zinc finger protein 787 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 126208 ncbi.nlm.nih.gov/gene/126208 |
| Ensembl ID | ENSG00000167775 |
| UniProt ID | Q6ZMY3 |
| OMIM ID | 618826 |
| HGNC ID | 25999 |
| Aliases | FLJ32709, MGC138499 |
Description
ZNF787 (zinc finger protein 787) is a protein-coding gene located on chromosome 19q13.43. It encodes a C2H2-type zinc finger protein that likely functions as a transcription factor involved in regulating gene expression. ZNF787 has been implicated in cellular processes such as proliferation and differentiation, and its dysregulation is associated with several cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of ZNF787 may promote cell proliferation and migration through transcriptional regulation of target genes. | PMID: 31525674 |
| Colorectal cancer | ZNF787 is upregulated in tumor tissues and correlates with poor prognosis; may influence Wnt/β-catenin signaling. | PMID: 32015517 |
| Hepatocellular carcinoma | ZNF787 expression is elevated and associated with tumor progression and metastasis. | PMID: 30872563 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.3 | Medium |
| Adrenal gland | 6.1 | Low |
| Bone marrow | 4.7 | Low |
| Brain | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Embryonic kidney cell line; moderate expression |
| HeLa | 9.8 | Cervical cancer cell line; moderate expression |
| MCF7 | 7.4 | Breast cancer cell line; low expression |
| HepG2 | 6.1 | Hepatocellular carcinoma cell line; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.1456G>A (p.Glu486Lys) | Missense | <0.01% | Unknown; rare variant in population databases |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ZNF787.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in ZNF787.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in ZNF787.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity | • RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| • metal ion binding | • nucleus |
| • regulation of transcription by RNA polymerase II |
Pathways
• No specific pathways curated for ZNF787 in major databases.
Protein Summary
ZNF787 encodes a C2H2-type zinc finger protein of 787 amino acids. It contains multiple zinc finger domains characteristic of transcription factors, suggesting a role in sequence-specific DNA binding and transcriptional regulation. The protein is localized to the nucleus and is expressed in various tissues, with highest levels in testis and thyroid. Its precise biological functions remain under investigation, but emerging evidence links ZNF787 to cancer cell proliferation and migration.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF787 Knockout HEK293 Cell Line | EDJ-KQ8869 | Human | 126208 | Details Get a Quote |
| ZNF787 Knockout A-549 Cell Line | EDJ-KQ35185 | Human | 126208 | Details Get a Quote |
| ZNF787 Knockout HCT 116 Cell Line | EDJ-KQ35186 | Human | 126208 | Details Get a Quote |
| ZNF787 Knockout HeLa Cell Line | EDJ-KQ35187 | Human | 126208 | Details Get a Quote |
