ZNF432: Zinc Finger Protein 432
A KRAB-Zinc Finger Transcription Factor with Emerging Roles in Gene Regulation and Cancer
Gene Information Card
| Symbol | ZNF432 |
|---|---|
| Full Name | zinc finger protein 432 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 9668 ncbi.nlm.nih.gov/gene/9668 |
| Ensembl ID | ENSG00000104884 |
| UniProt ID | O94892 |
| OMIM ID | 618829 |
| HGNC ID | 20826 |
| Aliases | KIAA1961, ZNF432L |
Description
ZNF432 encodes a zinc finger protein of the Krüppel-associated box (KRAB) subfamily. It contains multiple C2H2-type zinc finger domains and a KRAB domain, suggesting a role in transcriptional repression through recruitment of chromatin-modifying complexes. ZNF432 is widely expressed and may be involved in cellular differentiation and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential transcriptional dysregulation; ZNF432 expression altered in tumor samples | COSMIC; NCBI Gene |
| Colorectal cancer | Mutations and copy number alterations observed in cancer genomes | COSMIC; ClinVar |
| Prostate cancer | Expression changes linked to disease progression | NCBI Gene; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 8.5 | Low |
| Lung | 6.3 | Low |
| Liver | 4.1 | Low |
| Kidney | 5.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.1 | Moderate expression |
| HeLa | 9.8 | Low expression |
| MCF7 | 7.4 | Low expression |
| A549 | 6.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.1% | Unknown functional impact |
| c.567delA (p.Lys189fs) | Frameshift | <0.1% | Predicted loss of function |
| c.890G>A (p.Arg297Gln) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Lys189fs) likely lead to nonsense-mediated decay or truncated protein.
Gain of Function (GOF)
No gain-of-function mutations reported in curated databases.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • regulation of transcription by RNA polymerase II (GO:0006357) |
Pathways
• No curated pathway annotations in KEGG or Reactome for ZNF432.
Protein Summary
ZNF432 is a 748-amino acid protein containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. It localizes to the nucleus and is predicted to function as a transcriptional repressor. The protein is expressed in multiple tissues and cell lines, with highest levels in testis. Mutations in ZNF432 are rare but have been identified in cancer genomes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF432 Knockout HEK293 Cell Line | EDJ-KQ16269 | Human | 9668 | Details Get a Quote |
| ZNF432 Knockout HeLa Cell Line | EDJ-KQ18045 | Human | 9668 | Details Get a Quote |
| ZNF432 Knockout U2OS Cell Line | EDJ-KQ18046 | Human | 9668 | Details Get a Quote |
| ZNF432 Knockout A-549 Cell Line | EDJ-KQ47605 | Human | 9668 | Details Get a Quote |
| ZNF432 Knockout HCT 116 Cell Line | EDJ-KQ72165 | Human | 9668 | Details Get a Quote |
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