ZNF229: Zinc Finger Protein 229
A KRAB-ZFP transcription factor with potential roles in gene regulation and cancer
Gene Information Card
| Symbol | ZNF229 |
|---|---|
| Full Name | Zinc Finger Protein 229 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.12 |
| NCBI Gene ID | 7772 ncbi.nlm.nih.gov/gene/7772 |
| Ensembl ID | ENSG00000167601 |
| UniProt ID | Q9UEG4 |
| OMIM ID | None |
| HGNC ID | 13037 |
| Aliases | KIAA1845, ZNF229A |
Description
ZNF229 encodes a zinc finger protein of the Krüppel-associated box (KRAB) subfamily. These proteins typically function as transcriptional repressors by recruiting chromatin-modifying complexes. ZNF229 is located on chromosome 19q13.12 and is expressed in various tissues. Its exact biological functions are not fully characterized, but it may play roles in development and cellular differentiation. Altered expression has been observed in some cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Dysregulation of ZNF229 expression may contribute to oncogenesis through aberrant transcriptional repression or activation. | COSMIC; literature |
| Breast cancer | Overexpression of ZNF229 has been reported in breast cancer cell lines and tumor samples, suggesting a possible role in tumor progression. | COSMIC; PubMed |
| Prostate cancer | ZNF229 expression changes have been noted in prostate cancer, potentially affecting cell proliferation pathways. | COSMIC; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.2 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney cells |
| MCF7 | 15.8 | Breast cancer cell line |
| HeLa | 9.5 | Cervical cancer cell line |
| K562 | 7.3 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1000C>T | Missense | <0.1% | p.Arg334Cys; uncertain significance |
| c.1456G>A | Missense | <0.1% | p.Gly486Ser; uncertain significance |
| c.2101_2102insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants likely lead to loss of function, but no confirmed pathogenic examples are documented.
Gain of Function (GOF)
No gain-of-function mutations have been reported for ZNF229.
Dominant Negative (DN)
No dominant-negative mutations have been described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• No specific pathways are curated for ZNF229 in major databases.
Protein Summary
ZNF229 is a 748-amino acid protein containing multiple C2H2-type zinc finger domains and a KRAB domain at the N-terminus. The KRAB domain mediates interaction with KAP1/TRIM28, leading to transcriptional repression via histone modification. The zinc fingers are predicted to bind specific DNA sequences. The protein is localized to the nucleus and is expressed in a variety of tissues. Its precise target genes and physiological roles remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF229 Knockout HEK293 Cell Line | EDJ-KQ5404 | Human | 7772 | Details Get a Quote |
| ZNF229 Knockout A-549 Cell Line | EDJ-KQ29857 | Human | 7772 | Details Get a Quote |
| ZNF229 Knockout HeLa Cell Line | EDJ-KQ29859 | Human | 7772 | Details Get a Quote |
| ZNF229 Knockout HCT 116 Cell Line | EDJ-KQ71751 | Human | 7772 | Details Get a Quote |
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