ZNF227 Gene: Zinc Finger Protein 227 | Function, Expression & Disease

ZNF227 (zinc finger protein 227) is a protein-coding gene located on chromosome 19q13.43. It encodes a zinc finger protein belonging to the Krüppel-associated box (KRAB) domain-containing zinc finger family, which are transcriptional regulators involved in various cellular processes including development, differentiation, and apoptosis. ZNF227 is characterized by multiple C2H2-type zinc finger domains and a KRAB domain at the N-terminus, suggesting a role in transcriptional repression. The gene is expressed in multiple tissues and has been implicated in several cancers and other diseases, though its precise functions are still under investigation.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No specific pathways curated in major databases; likely involved in transcriptional regulation networks.

ZNF227 is a KRAB domain-containing zinc finger protein that likely functions as a transcriptional repressor. It contains multiple C2H2 zinc finger motifs that mediate sequence-specific DNA binding. The KRAB domain interacts with corepressors such as KAP1, leading to chromatin remodeling and gene silencing. ZNF227 is expressed in various tissues, with highest levels in testis, and is implicated in cancer biology, where its dysregulation may contribute to tumorigenesis. Further studies are needed to fully elucidate its target genes and physiological roles.