ZNF226: Zinc Finger Protein 226 – Gene Overview and Functional Insights
Comprehensive biomedical reference for ZNF226, including genomic annotation, expression, mutations, and disease associations.
Gene Information Card
| Symbol | ZNF226 |
|---|---|
| Full Name | zinc finger protein 226 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 7769 ncbi.nlm.nih.gov/gene/7769 |
| Ensembl ID | ENSG00000167380 |
| UniProt ID | Q9NX65 |
| OMIM ID | None |
| HGNC ID | 13036 |
| Aliases | ZNF226, zinc finger protein 226 |
Description
ZNF226 (zinc finger protein 226) is a protein-coding gene located on chromosome 19q13.43. It belongs to the Krüppel C2H2-type zinc finger protein family, which typically function as transcription factors. The encoded protein contains multiple C2H2 zinc finger domains and is predicted to be involved in DNA-binding and transcriptional regulation. Its specific biological roles and disease associations are not yet fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar, OMIM, or COSMIC as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.6 | Low |
| Brain | 3.2 | Low |
| Lung | 2.1 | Low |
| Liver | 1.8 | Low |
| Kidney | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Low expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.8 | Low expression |
| MCF7 | 2.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants in COSMIC or ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • DNA-binding transcription factor activity (GO:0003700) | • zinc ion binding (GO:0008270) |
| • nucleus (GO:0005634) | • regulation of transcription by RNA polymerase II (GO:0006357) |
Protein Summary
ZNF226 encodes a 548-amino acid protein with 12 C2H2-type zinc finger domains. It is predicted to localize to the nucleus and function as a DNA-binding transcription factor. The protein is expressed at low levels across multiple tissues, with highest relative expression in testis. Its molecular function and physiological roles remain largely uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF226 Knockout HEK293 Cell Line | EDJ-KQ6110 | Human | 7769 | Details Get a Quote |
| ZNF226 Knockout A-549 Cell Line | EDJ-KQ29854 | Human | 7769 | Details Get a Quote |
| ZNF226 Knockout HCT 116 Cell Line | EDJ-KQ29855 | Human | 7769 | Details Get a Quote |
| ZNF226 Knockout HeLa Cell Line | EDJ-KQ29856 | Human | 7769 | Details Get a Quote |
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