ZNF225: Zinc Finger Protein 225
Transcriptional regulator with C2H2-type zinc finger domains; limited functional characterization.
Gene Information Card
| Symbol | ZNF225 |
|---|---|
| Full Name | zinc finger protein 225 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 7768 ncbi.nlm.nih.gov/gene/7768 |
| Ensembl ID | ENSG00000105639 |
| UniProt ID | Q9UK10 |
| OMIM ID | 604076 |
| HGNC ID | 13024 |
| Aliases | KIAA0827, ZNF225A |
Description
ZNF225 encodes a zinc finger protein of the Krüppel-associated box (KRAB) subfamily, characterized by multiple C2H2-type zinc finger domains. The protein is predicted to function as a transcription repressor via KRAB-mediated recruitment of co-repressors. Its precise biological roles remain under investigation, with evidence suggesting involvement in gene regulation and potential links to cellular differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease association | Not established | No direct evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain (cerebellum) | 8.2 | Low |
| Thyroid | 6.1 | Low |
| Lung | 4.3 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | Moderate expression |
| K562 | 9.8 | Low expression |
| HeLa | 7.4 | Low expression |
| HepG2 | 3.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.01% | Unknown functional impact |
| c.567delG (p.Gly190Valfs*12) | Frameshift deletion | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift deletions likely lead to nonsense-mediated decay or truncated protein.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Not assigned to any curated pathway
Protein Summary
ZNF225 is a 707-amino acid protein containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. It localizes to the nucleus and is predicted to bind DNA and repress transcription. Expression is highest in testis and certain brain regions. No disease-causing mutations have been validated in major databases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF225 Knockout HEK293 Cell Line | EDJ-KQ6112 | Human | 7768 | Details Get a Quote |
| ZNF225 Knockout A-549 Cell Line | EDJ-KQ29863 | Human | 7768 | Details Get a Quote |
| ZNF225 Knockout HCT 116 Cell Line | EDJ-KQ29864 | Human | 7768 | Details Get a Quote |
| ZNF225 Knockout HeLa Cell Line | EDJ-KQ29865 | Human | 7768 | Details Get a Quote |
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