ZNF222: Zinc Finger Protein 222
A Krüppel-associated box (KRAB) domain-containing zinc finger transcription factor with potential roles in transcriptional regulation and cancer.
Gene Information Card
| Symbol | ZNF222 |
|---|---|
| Full Name | zinc finger protein 222 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 7573 ncbi.nlm.nih.gov/gene/7573 |
| Ensembl ID | ENSG00000167552 |
| UniProt ID | Q9UK13 |
| OMIM ID | None |
| HGNC ID | 13036 |
| Aliases | ZNF222, ZNF222_HUMAN, FLJ32115 |
Description
ZNF222 (zinc finger protein 222) is a protein-coding gene located on chromosome 19q13.43. It encodes a member of the Krüppel C2H2-type zinc finger protein family, characterized by a KRAB (Krüppel-associated box) domain at the N-terminus and multiple C2H2 zinc finger motifs. The protein is predicted to function as a transcription factor involved in transcriptional repression. Expression data suggest broad but low-level expression across many tissues. The gene has been implicated in various cancers, including breast and lung cancer, through mutation and expression analyses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression and somatic mutations may contribute to tumorigenesis via dysregulation of target genes. | COSMIC; literature |
| Lung cancer | Somatic mutations and copy number alterations observed in lung adenocarcinoma samples. | COSMIC; literature |
| Colorectal cancer | Mutations reported in colorectal cancer cell lines and primary tumors. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.3 | Low |
| Brain | 1.1 | Low |
| Lung | 0.8 | Low |
| Breast | 0.6 | Low |
| Colon | 0.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 0.9 | Low expression |
| A549 (lung cancer) | 0.7 | Low expression |
| HCT116 (colorectal cancer) | 0.6 | Low expression |
| HEK293 (embryonic kidney) | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | <0.1% | Unknown; predicted possibly damaging |
| c.250G>A (p.Gly84Ser) | Missense | <0.1% | Unknown; predicted benign |
| c.400_401insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.400_401insA) are predicted to cause premature truncation and loss of zinc finger domains, likely resulting in loss of DNA-binding and transcriptional repression activity.
Gain of Function (GOF)
No evidence for gain-of-function mutations in ZNF222.
Dominant Negative (DN)
No evidence for dominant-negative mutations in ZNF222.
View complete mutation data：
Gene Ontology (GO)
Pathways
• No specific pathways curated in Reactome or KEGG for ZNF222.
Protein Summary
ZNF222 is a 532-amino acid protein containing a KRAB domain (residues 1-75) and 12 C2H2-type zinc finger motifs (residues 100-520). The KRAB domain mediates transcriptional repression through recruitment of co-repressors such as KAP1/TRIM28. The zinc fingers are predicted to bind specific DNA sequences, though target genes remain largely unknown. The protein localizes to the nucleus and is expressed at low levels in most tissues. Structural predictions indicate a multi-zinc finger array typical of KRAB-ZNF transcription factors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF222 Knockout HEK293 Cell Line | EDJ-KQ6069 | Human | 7673 | Details Get a Quote |
| ZNF222 Knockout A-549 Cell Line | EDJ-KQ29766 | Human | 7673 | Details Get a Quote |
| ZNF222 Knockout HCT 116 Cell Line | EDJ-KQ29767 | Human | 7673 | Details Get a Quote |
| ZNF222 Knockout HeLa Cell Line | EDJ-KQ29768 | Human | 7673 | Details Get a Quote |
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