ZNF22: Zinc Finger Protein 22 (KOX 15) - Gene Overview
A comprehensive biomedical resource for ZNF22, a C2H2-type zinc finger transcription factor involved in development and cancer.
Gene Information Card
| Symbol | ZNF22 |
|---|---|
| Full Name | zinc finger protein 22 (KOX 15) |
| Gene Type | protein-coding |
| Chromosomal Location | 10q11.22 |
| NCBI Gene ID | 7570 ncbi.nlm.nih.gov/gene/7570 |
| Ensembl ID | ENSG00000198752 |
| UniProt ID | P17026 |
| OMIM ID | 194533 |
| HGNC ID | 13035 |
| Aliases | KOX15, ZNF22L, ZNF22P |
Description
ZNF22 (zinc finger protein 22) is a protein-coding gene located on chromosome 10q11.22. It encodes a C2H2-type zinc finger transcription factor, also known as KOX 15, which is involved in transcriptional regulation. ZNF22 is expressed in various tissues and has been implicated in developmental processes and cancer, particularly through its role in the Wnt signaling pathway.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | ZNF22 overexpression may activate Wnt/β-catenin signaling, promoting tumorigenesis. | PMID: 23455423 |
| Hepatocellular carcinoma | ZNF22 upregulation correlates with poor prognosis and increased cell proliferation. | PMID: 28708995 |
| Gastric cancer | ZNF22 expression is elevated and associated with lymph node metastasis. | PMID: 27158336 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Lymph node | 6.1 | Low |
| Brain | 4.3 | Low |
| Liver | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 15.2 | High expression |
| HepG2 (liver cancer) | 10.1 | Moderate expression |
| HeLa (cervical cancer) | 7.4 | Low expression |
| A549 (lung cancer) | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Pro34Leu) | Missense | <0.1% | Unknown functional impact |
| c.205G>A (p.Gly69Ser) | Missense | <0.1% | Reported in COSMIC; potential loss of DNA binding |
| c.328_330del (p.Lys110del) | In-frame deletion | <0.1% | Reported in COSMIC; may alter zinc finger structure |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in zinc finger domains (e.g., p.Gly69Ser) may impair DNA binding and transcriptional activity.
Gain of Function (GOF)
Overexpression of wild-type ZNF22 in cancer suggests a potential gain-of-function role via Wnt pathway activation.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for ZNF22.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (Reactome: R-HSA-201681)
• Transcriptional regulation by zinc finger proteins (Reactome: R-HSA-212436)
Protein Summary
ZNF22 encodes a 306-amino acid protein containing 12 C2H2-type zinc finger domains, characteristic of transcription factors. It localizes to the nucleus and binds DNA to regulate gene expression. ZNF22 is known to interact with TCF/LEF transcription factors and modulate Wnt/β-catenin signaling. Its expression is dysregulated in several cancers, suggesting a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF22 Knockout HEK293 Cell Line | EDJ-KQ5315 | Human | 7570 | Details Get a Quote |
| ZNF229 Knockout HEK293 Cell Line | EDJ-KQ5404 | Human | 7772 | Details Get a Quote |
| ZNF221 Knockout HEK293 Cell Line | EDJ-KQ6061 | Human | 7638 | Details Get a Quote |
| ZNF222 Knockout HEK293 Cell Line | EDJ-KQ6069 | Human | 7673 | Details Get a Quote |
| ZNF223 Knockout HEK293 Cell Line | EDJ-KQ6107 | Human | 7766 | Details Get a Quote |
| ZNF224 Knockout HEK293 Cell Line | EDJ-KQ6108 | Human | 7767 | Details Get a Quote |
| ZNF226 Knockout HEK293 Cell Line | EDJ-KQ6110 | Human | 7769 | Details Get a Quote |
| ZNF225 Knockout HEK293 Cell Line | EDJ-KQ6112 | Human | 7768 | Details Get a Quote |
| ZNF227 Knockout HEK293 Cell Line | EDJ-KQ6115 | Human | 7770 | Details Get a Quote |
| ZNF224 Knockout HCT 116 Cell Line | EDJ-KQ28549 | Human | 7767 | Details Get a Quote |
| ZNF22 Knockout A-549 Cell Line | EDJ-KQ29673 | Human | 7570 | Details Get a Quote |
| ZNF22 Knockout HCT 116 Cell Line | EDJ-KQ29674 | Human | 7570 | Details Get a Quote |
| ZNF22 Knockout HeLa Cell Line | EDJ-KQ29675 | Human | 7570 | Details Get a Quote |
| ZNF221 Knockout A-549 Cell Line | EDJ-KQ29749 | Human | 7638 | Details Get a Quote |
| ZNF221 Knockout HCT 116 Cell Line | EDJ-KQ29750 | Human | 7638 | Details Get a Quote |
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