ZNF217: Zinc Finger Protein 217 – A Key Oncogene in Cancer Progression
Comprehensive gene card, expression, mutations, and disease associations for ZNF217
Gene Information Card
| Symbol | ZNF217 |
|---|---|
| Full Name | zinc finger protein 217 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.2 |
| NCBI Gene ID | 7764 ncbi.nlm.nih.gov/gene/7764 |
| Ensembl ID | ENSG00000171940 |
| UniProt ID | O75362 |
| OMIM ID | 602967 |
| HGNC ID | 13018 |
| Aliases | ZABC1, ZNF217FLJ10099 |
Description
ZNF217 encodes a zinc finger protein that functions as a transcription factor and is frequently amplified in human cancers. It is located on chromosome 20q13.2, a region commonly gained in breast, ovarian, and other solid tumors. ZNF217 promotes cell proliferation, survival, and metastasis by regulating genes involved in apoptosis, cell cycle, and epithelial-mesenchymal transition.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | Amplification and overexpression of ZNF217 drive tumorigenesis by inhibiting apoptosis and promoting cell cycle progression. | NCBI Gene, COSMIC |
| Ovarian Cancer | ZNF217 amplification at 20q13.2 is associated with poor prognosis and chemoresistance. | COSMIC, ClinVar |
| Colorectal Cancer | ZNF217 overexpression correlates with advanced stage and metastasis via EMT induction. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.5 nTPM | Medium |
| Ovary | 8.3 nTPM | Low |
| Colon | 6.7 nTPM | Low |
| Lung | 5.1 nTPM | Low |
| Liver | 3.2 nTPM | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 nTPM | High expression; associated with hormone receptor status |
| OVCAR3 (ovarian cancer) | 10.8 nTPM | Moderate expression; linked to cisplatin resistance |
| HCT116 (colorectal cancer) | 9.4 nTPM | Moderate expression; promotes invasion |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.1% | Unknown functional impact; reported in COSMIC |
| c.567G>A (p.Gly189Arg) | Missense | <0.1% | Potential loss of DNA-binding affinity |
| Amplification | Copy number gain | 5-15% in breast cancer | Gain-of-function; drives oncogenic signaling |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Gly189Arg) may reduce DNA-binding capacity.
Gain of Function (GOF)
Gene amplification leads to increased ZNF217 expression, promoting cell survival and proliferation.
Dominant Negative (DN)
Not reported for ZNF217.
View complete mutation data：
Gene Ontology (GO)
Pathways
• PI3K/Akt signaling pathway
• Apoptosis regulation
• Epithelial-mesenchymal transition (EMT)
Protein Summary
ZNF217 is a 1048-amino acid zinc finger transcription factor containing eight C2H2-type zinc finger domains. It localizes to the nucleus and regulates gene expression by binding to specific DNA sequences. Overexpression of ZNF217 promotes cell survival, inhibits apoptosis, and enhances metastatic potential, making it a key oncoprotein in multiple cancer types.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF217 Knockout HEK293 Cell Line | EDJ-KQ15483 | Human | 7764 | Details Get a Quote |
| ZNF217 Knockout A-549 Cell Line | EDJ-KQ47527 | Human | 7764 | Details Get a Quote |
| ZNF217 Knockout HCT 116 Cell Line | EDJ-KQ47529 | Human | 7764 | Details Get a Quote |
| ZNF217 Knockout HeLa Cell Line | EDJ-KQ47530 | Human | 7764 | Details Get a Quote |
| ZNF217 Knockout MDA-MB-231 Cell Line | EDJ-KZ92 | Human | 7764 | Details Get a Quote |
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