ZNF202
Zinc Finger Protein 202: Transcriptional Repressor in Lipid Metabolism and Potential Tumor Suppressor
Gene Information Card
| Symbol | ZNF202 |
|---|---|
| Full Name | zinc finger protein 202 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q23.3 |
| NCBI Gene ID | 7753 ncbi.nlm.nih.gov/gene/7753 |
| Ensembl ID | ENSG00000166226 |
| UniProt ID | O95125 |
| OMIM ID | 603055 |
| HGNC ID | 13095 |
| Aliases | ZNF202, MGC138499, MGC138501 |
Description
ZNF202 encodes a zinc finger protein of the Krüppel-like family, functioning as a transcriptional repressor. It binds to specific DNA sequences (e.g., the sterol regulatory element) and recruits histone deacetylases to silence target genes involved in lipid metabolism, including apolipoproteins and lipoprotein lipase. ZNF202 is implicated in hypobetalipoproteinemia and may act as a tumor suppressor in certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hypobetalipoproteinemia, familial, 2 (FHBL2) | Loss-of-function mutations in ZNF202 impair repression of apolipoprotein genes, leading to reduced plasma LDL cholesterol levels. | OMIM #605019; PMID: 10655055 |
| Hypertriglyceridemia | ZNF202 variants may alter regulation of lipoprotein lipase and other triglyceride-related genes, contributing to elevated triglycerides. | PMID: 11734858 |
| Cancer (potential tumor suppressor) | ZNF202 downregulation or mutation may promote oncogenesis via dysregulated lipid metabolism and cell proliferation. | COSMIC; PMID: 23481259 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Small intestine | 8.3 | Medium |
| Adipose tissue | 6.1 | Low |
| Kidney | 4.7 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| Caco-2 | 9.8 | Colorectal adenocarcinoma cell line |
| MCF7 | 3.4 | Breast cancer cell line |
| HEK293 | 1.2 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Loss of start codon; likely loss of function |
| c.124C>T (p.Arg42*) | Nonsense | <0.01% | Premature stop; loss of function |
| c.487G>A (p.Gly163Arg) | Missense | 0.02% | Reduced DNA binding; partial loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg42*) lead to truncated protein lacking zinc finger domains, abolishing transcriptional repression.
Gain of Function (GOF)
No gain-of-function mutations reported in ZNF202.
Dominant Negative (DN)
Missense mutations in the DNA-binding domain (e.g., p.Gly163Arg) may interfere with wild-type ZNF202 function, but dominant-negative effects are not well established.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Lipoprotein metabolism (Reactome: R-HSA-174824)
• Transcriptional regulation by ZNF202 (PMID: 10655055)
Protein Summary
ZNF202 is a 648-amino acid nuclear protein containing 13 C2H2-type zinc fingers. It functions as a sequence-specific transcriptional repressor, binding to the sterol regulatory element (SRE) and recruiting corepressors such as histone deacetylases. ZNF202 represses genes involved in lipid metabolism, including APOA1, APOC3, and LPL. Mutations in ZNF202 cause familial hypobetalipoproteinemia type 2, and altered expression is observed in cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF202 Knockout HEK293 Cell Line | EDJ-KQ6102 | Human | 7753 | Details Get a Quote |
| ZNF202 Knockout A-549 Cell Line | EDJ-KQ28536 | Human | 7753 | Details Get a Quote |
| ZNF202 Knockout HCT 116 Cell Line | EDJ-KQ29838 | Human | 7753 | Details Get a Quote |
| ZNF202 Knockout HeLa Cell Line | EDJ-KQ29839 | Human | 7753 | Details Get a Quote |
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