ZNF124: Zinc Finger Protein 124
A KRAB domain-containing zinc finger transcription factor with potential roles in gene regulation and cancer
Gene Information Card
| Symbol | ZNF124 |
|---|---|
| Full Name | zinc finger protein 124 |
| Gene Type | protein-coding |
| Chromosomal Location | 1q44 |
| NCBI Gene ID | 7678 ncbi.nlm.nih.gov/gene/7678 |
| Ensembl ID | ENSG00000143178 |
| UniProt ID | Q15928 |
| OMIM ID | 604660 |
| HGNC ID | 12928 |
| Aliases | HZF-16, ZNF124A, ZNF124B |
Description
ZNF124 encodes a zinc finger protein of the Krüppel-associated box (KRAB) domain-containing family. The protein localizes to the nucleus and functions as a transcriptional repressor via its KRAB domain. ZNF124 is involved in regulating cell proliferation and differentiation, and its dysregulation has been implicated in several cancers, including breast and colorectal cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of ZNF124 may promote cell proliferation through transcriptional repression of tumor suppressor genes | PMID: 25605248 |
| Colorectal cancer | ZNF124 upregulation correlates with poor prognosis and increased metastatic potential | PMID: 28723891 |
| Hepatocellular carcinoma | ZNF124 silencing reduces cell viability and induces apoptosis in liver cancer cell lines | PMID: 31065123 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.3 | Low |
| Lymph node | 6.1 | Low |
| Breast | 4.2 | Low |
| Colon | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HCT116 (colorectal cancer) | 11.7 | Moderate expression |
| HepG2 (liver cancer) | 9.4 | Moderate expression |
| K562 (leukemia) | 7.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | 0.001% (gnomAD) | Unknown functional effect |
| c.1234G>A (p.Gly412Arg) | Missense | 0.0005% (gnomAD) | Predicted damaging (SIFT) |
| c.1456_1457insA (p.Thr486Asnfs*12) | Frameshift | <0.001% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertion c.1456_1457insA leads to premature truncation and loss of zinc finger domains.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No evidence for dominant-negative effects currently available.
View complete mutation data：
Gene Ontology (GO)
Pathways
• No specific curated pathways in Reactome or KEGG for ZNF124
Protein Summary
ZNF124 is a 548-amino acid nuclear protein containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. The KRAB domain mediates transcriptional repression by recruiting chromatin-modifying complexes such as SETDB1 and TRIM28. The zinc finger array is responsible for sequence-specific DNA binding. ZNF124 is expressed at low levels in most normal tissues but is upregulated in several cancer types, suggesting a role in oncogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZNF124 Knockout HEK293 Cell Line | EDJ-KQ6068 | Human | 7678 | Details Get a Quote |
| ZNF124 Knockout A-549 Cell Line | EDJ-KQ29763 | Human | 7678 | Details Get a Quote |
| ZNF124 Knockout HCT 116 Cell Line | EDJ-KQ29764 | Human | 7678 | Details Get a Quote |
| ZNF124 Knockout HeLa Cell Line | EDJ-KQ29765 | Human | 7678 | Details Get a Quote |
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