ZNF114 Gene - Zinc Finger Protein 114: Function, Expression, and Disease Associations

ZNF114 (zinc finger protein 114) is a protein-coding gene located on chromosome 19q13.41. It encodes a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, which are transcriptional repressors involved in diverse biological processes including development, differentiation, and apoptosis. The protein contains multiple C2H2-type zinc finger domains and a KRAB domain, suggesting it functions as a DNA-binding transcription factor. Expression is detected in various tissues, with highest levels in the testis and brain. Limited functional studies suggest potential roles in cellular signaling and disease, but detailed mechanisms remain to be elucidated.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• No curated pathways in KEGG or Reactome

ZNF114 is a 546-amino acid protein containing a KRAB domain at the N-terminus and 12 C2H2-type zinc finger motifs. The KRAB domain mediates transcriptional repression through recruitment of co-repressor complexes, while the zinc fingers facilitate sequence-specific DNA binding. The protein is predicted to localize to the nucleus and may regulate target genes involved in cell proliferation and differentiation. Structural and functional characterization remains limited.