ZFP36L2 Gene
ZFP36 Ring Finger Protein Like 2
Gene Information Card
| Symbol | ZFP36L2 |
|---|---|
| Full Name | ZFP36 ring finger protein like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p21 |
| NCBI Gene ID | 678 ncbi.nlm.nih.gov/gene/678 |
| Ensembl ID | ENSG00000152518 |
| UniProt ID | Q07352 |
| OMIM ID | 602277 |
| HGNC ID | 12863 |
| Aliases | ERF2, TIS11D, BRF2, RNF162C |
Description
ZFP36L2 encodes a member of the TIS11 family of CCCH tandem zinc finger proteins. The protein binds to AU-rich elements (AREs) in the 3' untranslated regions of target mRNAs, promoting their deadenylation and decay. It plays a critical role in post-transcriptional regulation of gene expression, particularly in immune response, hematopoiesis, and cell proliferation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute myeloid leukemia | Loss of ZFP36L2 expression leads to increased stability of oncogenic mRNAs (e.g., MYC, BCL2), promoting leukemogenesis. | PMID: 24829207 |
| B-cell lymphoma | ZFP36L2 acts as a tumor suppressor by destabilizing mRNAs encoding pro-survival factors. | PMID: 25691752 |
| Inflammatory diseases | Dysregulation of ZFP36L2 alters cytokine mRNA stability, contributing to chronic inflammation. | PMID: 21217775 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 10.3 | Medium |
| Lymph node | 8.9 | Medium |
| Thymus | 7.2 | Low |
| Lung | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 15.8 | High expression |
| HEK293 (embryonic kidney) | 6.5 | Moderate expression |
| HeLa (cervical carcinoma) | 5.2 | Moderate expression |
| HepG2 (liver carcinoma) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163*) | Nonsense | <0.1% | Loss of function; truncated protein lacking zinc finger domains |
| c.1012A>G (p.Thr338Ala) | Missense | <0.01% | Unknown functional effect |
| c.124_125insA (p.Leu42fs) | Frameshift | <0.01% | Loss of function; predicted NMD |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations that truncate the protein or disrupt the CCCH zinc finger domains lead to loss of mRNA destabilization activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported in ZFP36L2.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for ZFP36L2.
View complete mutation data：
Gene Ontology (GO)
| • mRNA binding (GO:0003729) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) | • mRNA catabolic process (GO:0006402) |
| • negative regulation of mRNA splicing (GO:0048025) | • miRNA binding (GO:0035198) |
Pathways
• mRNA surveillance pathway (Reactome: R-HSA-72163)
• AU-rich element (ARE) mediated mRNA decay (Reactome: R-HSA-450531)
Protein Summary
ZFP36L2 is a 482-amino acid protein containing two CCCH-type zinc finger domains that mediate sequence-specific binding to AU-rich elements (AREs) in target mRNAs. It recruits the CCR4-NOT deadenylase complex to promote mRNA deadenylation and decay. The protein is predominantly cytoplasmic but can shuttle to the nucleus. Post-translational modifications include phosphorylation by MAP kinases, which regulates its stability and activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZFP36L2 Knockout HEK293 Cell Line | EDJ-KQ2957 | Human | 678 | Details Get a Quote |
| ZFP36L2 Knockout HCT 116 Cell Line | EDJ-KQ24099 | Human | 678 | Details Get a Quote |
| ZFP36L2 Knockout HeLa Cell Line | EDJ-KQ24100 | Human | 678 | Details Get a Quote |
| ZFP36L2 Knockout A-549 Cell Line | EDJ-KQ22726 | Human | 678 | Details Get a Quote |
