ZC3H11A Gene
ZC3H11A: Zinc Finger CCCH-Type Containing 11A
Gene Information Card
| Symbol | ZC3H11A |
|---|---|
| Full Name | Zinc Finger CCCH-Type Containing 11A |
| Gene Type | Protein coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 9877 ncbi.nlm.nih.gov/gene/9877 |
| Ensembl ID | ENSG00000158604 |
| UniProt ID | O75152 |
| OMIM ID | 613265 |
| HGNC ID | 28987 |
| Aliases | ZNF1129, FLJ21908, MGC138290 |
Description
ZC3H11A encodes a zinc finger protein of the CCCH-type family, which is involved in RNA processing and gene expression regulation. The protein contains a CCCH-type zinc finger domain that mediates RNA binding and is implicated in post-transcriptional regulation. ZC3H11A is ubiquitously expressed and has been associated with cellular stress responses and viral replication.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not applicable | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.2 | Medium |
| Lung | 7.1 | Medium |
| Brain | 5.3 | Low |
| Liver | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | RNA-seq data |
| HeLa | 8.9 | RNA-seq data |
| K562 | 7.5 | RNA-seq data |
| A549 | 6.8 | RNA-seq data |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • RNA binding | • zinc ion binding |
| • nucleus | • cytoplasm |
| • regulation of gene expression |
Pathways
• No specific pathway annotations in KEGG or Reactome
Protein Summary
ZC3H11A is a 746-amino acid protein containing a CCCH-type zinc finger domain. It localizes to the nucleus and cytoplasm and is involved in RNA metabolism. The protein interacts with splicing factors and may play a role in mRNA export and stability. Its expression is regulated during the cell cycle and in response to viral infection.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ZC3H11A Knockout HEK293 Cell Line | EDJ-KQ50914 | Human | 9877 | Details Get a Quote |
| ZC3H11A Knockout HeLa Cell Line | EDJ-KQ55270 | Human | 9877 | Details Get a Quote |
| ZC3H11A Knockout A-549 Cell Line | EDJ-KQ63749 | Human | 9877 | Details Get a Quote |
| ZC3H11A Knockout HCT 116 Cell Line | EDJ-KQ72209 | Human | 9877 | Details Get a Quote |
