YTHDF2
YTH N6-Methyladenosine RNA Binding Protein F2
Gene Information Card
| Symbol | YTHDF2 |
|---|---|
| Full Name | YTH N6-methyladenosine RNA binding protein F2 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p35.3 |
| NCBI Gene ID | 51441 ncbi.nlm.nih.gov/gene/51441 |
| Ensembl ID | ENSG00000198492 |
| UniProt ID | Q9Y5A9 |
| OMIM ID | 610522 |
| HGNC ID | 18317 |
| Aliases | HGRG8, m6A-binding protein, YTH domain family member 2 |
Description
YTHDF2 is a member of the YTH domain family of RNA-binding proteins that specifically recognize and bind N6-methyladenosine (m6A)-modified RNAs. It plays a key role in post-transcriptional regulation by promoting the degradation of m6A-containing transcripts, thereby influencing mRNA stability, gene expression, and cellular processes such as stem cell differentiation, immune response, and tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Myeloid Leukemia | YTHDF2 overexpression promotes leukemogenesis by destabilizing m6A-modified tumor suppressor mRNAs | PMID: 29507755 |
| Hepatocellular Carcinoma | YTHDF2 downregulation correlates with poor prognosis and increased cell proliferation | PMID: 30401839 |
| Colorectal Cancer | YTHDF2 regulates Wnt/β-catenin signaling via m6A-dependent mRNA decay | PMID: 31570779 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | High |
| Bone Marrow | 8.3 | Medium |
| Spleen | 7.1 | Medium |
| Liver | 4.2 | Low |
| Brain | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 (leukemia) | 10.2 | High expression |
| HepG2 (liver cancer) | 6.5 | Moderate expression |
| HEK293 (embryonic kidney) | 5.1 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1123C>T (p.Arg375*) | Nonsense | <0.1% (COSMIC) | Loss of function; truncated protein |
| c.1456G>A (p.Gly486Ser) | Missense | <0.1% (COSMIC) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutation p.Arg375* leads to premature stop codon and loss of m6A-binding activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • N6-methyladenosine-containing RNA binding (GO:1990247) | • mRNA catabolic process (GO:0006402) |
| • cytoplasmic stress granule (GO:0010494) | • regulation of mRNA stability (GO:0043488) |
Pathways
• m6A-mediated mRNA decay
• RNA degradation
Protein Summary
YTHDF2 is a 579-amino acid protein containing an N-terminal proline-rich region and a C-terminal YTH domain that specifically recognizes m6A-modified RNAs. It localizes to cytoplasmic foci and stress granules, where it recruits the CCR4-NOT deadenylase complex to promote deadenylation and degradation of target mRNAs. YTHDF2 is essential for embryonic stem cell self-renewal and differentiation, and its dysregulation is implicated in multiple cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| YTHDF2 Knockout HEK293 Cell Line | EDJ-KQ1055 | Human | 51441 | Details Get a Quote |
| YTHDF2 Knockout A-549 Cell Line | EDJ-KQ20172 | Human | 51441 | Details Get a Quote |
| YTHDF2 Knockout HCT 116 Cell Line | EDC07749 | Human | 51441 | Details Get a Quote |
| YTHDF2 Knockout HeLa Cell Line | EDJ-KQ20174 | Human | 51441 | Details Get a Quote |
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