YBX3 Gene - Y-Box Binding Protein 3
A member of the Y-box binding protein family involved in transcriptional and translational regulation, with roles in cellular proliferation and differentiation.
Gene Information Card
| Symbol | YBX3 |
|---|---|
| Full Name | Y-Box Binding Protein 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 12p13.1 |
| NCBI Gene ID | 8531 ncbi.nlm.nih.gov/gene/8531 |
| Ensembl ID | ENSG00000160180 |
| UniProt ID | P16989 |
| OMIM ID | 603437 |
| HGNC ID | 12819 |
| Aliases | CSDA, DBPA, MSY3, YB-3, ZONAB |
Description
YBX3 (Y-Box Binding Protein 3) encodes a member of the Y-box binding protein family, which contains a cold-shock domain. This protein functions as a DNA- and RNA-binding protein, involved in transcriptional regulation, mRNA splicing, and translational control. It plays roles in cell proliferation, differentiation, and stress response. YBX3 is also known as CSDA (cold shock domain protein A) and ZONAB (zonula occludens-1 associated nucleic acid binding protein).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | YBX3 overexpression promotes cell proliferation and invasion via transcriptional regulation of target genes | PMID: 25605248 |
| Colorectal cancer | YBX3 upregulation correlates with poor prognosis and enhances Wnt/β-catenin signaling | PMID: 29367608 |
| Hepatocellular carcinoma | YBX3 knockdown reduces tumor growth and metastasis in vitro and in vivo | PMID: 31065109 |
| Gastric cancer | YBX3 expression is associated with tumor stage and lymph node metastasis | PMID: 31591465 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 15.2 | Medium |
| Kidney | 10.1 | Medium |
| Liver | 7.8 | Low |
| Lung | 9.4 | Low |
| Ovary | 11.6 | Medium |
| Pancreas | 6.2 | Low |
| Prostate | 13.0 | Medium |
| Skin | 5.1 | Low |
| Testis | 18.7 | High |
| Thyroid | 8.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.3 | Cervical cancer cell line |
| MCF7 | 11.2 | Breast cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| HepG2 | 10.5 | Liver cancer cell line |
| K562 | 16.1 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | p.Met1Val; potential loss of start codon |
| c.100C>T | Missense | <0.01% | p.Arg34Cys; cold-shock domain variant |
| c.200G>A | Missense | <0.01% | p.Arg67His; functional impact unknown |
| c.350T>C | Missense | <0.01% | p.Leu117Pro; may affect protein stability |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants in the cold-shock domain (e.g., p.Arg34Cys) may impair DNA/RNA binding, reducing transcriptional activity.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in YBX3.
Dominant Negative (DN)
Not established for YBX3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway
• mRNA surveillance pathway
• RNA transport
Protein Summary
YBX3 is a 372-amino acid protein containing a conserved cold-shock domain (CSD) at the N-terminus, which mediates nucleic acid binding. It shuttles between nucleus and cytoplasm, regulating transcription and translation. YBX3 interacts with tight junction protein ZO-1 (TJP1) and modulates cell proliferation. Overexpression in multiple cancers suggests an oncogenic role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| YBX3 Knockout HEK293 Cell Line | EDJ-KQ3316 | Human | 8531 | Details Get a Quote |
| YBX3 Knockout A-549 Cell Line | EDJ-KQ24921 | Human | 8531 | Details Get a Quote |
| YBX3 Knockout HCT 116 Cell Line | EDJ-KQ24922 | Human | 8531 | Details Get a Quote |
| YBX3 Knockout HeLa Cell Line | EDJ-KQ24923 | Human | 8531 | Details Get a Quote |
