WTAP Gene: Wilms Tumor 1 Associated Protein
Key regulator of N6-methyladenosine (m6A) RNA methylation and gene expression
Gene Information Card
| Symbol | WTAP |
|---|---|
| Full Name | Wilms tumor 1 associated protein |
| Gene Type | Protein coding |
| Chromosomal Location | 6q25.3 |
| NCBI Gene ID | 9589 ncbi.nlm.nih.gov/gene/9589 |
| Ensembl ID | ENSG00000146457 |
| UniProt ID | Q15007 |
| OMIM ID | 617811 |
| HGNC ID | 12836 |
| Aliases | MUM1, FLJ10073, KIAA0105 |
Description
WTAP (Wilms Tumor 1 Associated Protein) encodes a nuclear protein that interacts with Wilms tumor 1 (WT1) and is a core component of the N6-methyltransferase complex responsible for N6-methyladenosine (m6A) modification of RNA. WTAP is essential for RNA splicing, cell cycle regulation, and embryonic development. It is widely expressed and implicated in various cancers, including acute myeloid leukemia, glioblastoma, and breast cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Myeloid Leukemia | WTAP overexpression promotes leukemogenesis via m6A-dependent regulation of target genes | PMID: 29713082 |
| Glioblastoma | WTAP enhances tumor growth and invasion through m6A modification of oncogenic transcripts | PMID: 30389920 |
| Breast Cancer | WTAP upregulation correlates with poor prognosis and promotes metastasis | PMID: 31570779 |
| Wilms Tumor | WTAP interacts with WT1; altered expression may contribute to tumorigenesis | PMID: 10646847 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 42.3 | High |
| Bone Marrow | 28.1 | Medium |
| Brain | 18.7 | Medium |
| Liver | 12.4 | Low |
| Heart | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 35.2 | Embryonic kidney cell line |
| K562 | 29.8 | Leukemia cell line |
| HeLa | 22.5 | Cervical cancer cell line |
| MCF7 | 18.1 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112C>T (p.Arg38Trp) | Missense | 0.02% | Unknown functional impact |
| c.457G>A (p.Glu153Lys) | Missense | 0.01% | Reported in COSMIC |
| c.784_785insA (p.Thr262AsnfsTer5) | Frameshift | 0.005% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of WTAP function, impairing m6A methylation.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in WTAP.
Dominant Negative (DN)
No evidence for dominant-negative effects in WTAP.
View complete mutation data：
Gene Ontology (GO)
| • GO:0003723 - RNA binding | • GO:0005634 - nucleus |
| • GO:0006397 - mRNA processing | • GO:0008170 - N-methyltransferase activity |
| • GO:0016070 - RNA metabolic process | • GO:0032259 - methylation |
Pathways
• m6A methylation pathway (Reactome: R-HSA-6782315)
• RNA processing (Reactome: R-HSA-8953854)
Protein Summary
WTAP is a 396-amino acid nuclear protein (UniProt Q15007) that forms a complex with METTL3 and METTL14 to catalyze N6-methyladenosine (m6A) modification of RNA. It contains a conserved coiled-coil domain and interacts with WT1. WTAP is involved in RNA splicing, cell cycle progression, and differentiation. Its dysregulation is linked to multiple cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WTAP Knockout HEK293 Cell Line | EDJ-KQ50885 | Human | 9589 | Details Get a Quote |
| WTAP Knockout HeLa Cell Line | EDJ-KQ55202 | Human | 9589 | Details Get a Quote |
| WTAP Knockout A-549 Cell Line | EDJ-KQ63685 | Human | 9589 | Details Get a Quote |
| WTAP Knockout HCT 116 Cell Line | EDJ-KQ72147 | Human | 9589 | Details Get a Quote |
| WTAP Knockout HEK293T Cell Line | EDC07689 | Human | 9589 | Details Get a Quote |
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