WNT8A
Wnt Family Member 8A
Gene Information Card
| Symbol | WNT8A |
|---|---|
| Full Name | Wnt Family Member 8A |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.2 |
| NCBI Gene ID | 7478 ncbi.nlm.nih.gov/gene/7478 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q9H1J5 |
| OMIM ID | 606359 |
| HGNC ID | 12789 |
| Aliases | WNT8A, Wnt-8a, WNT8A_HUMAN |
Description
WNT8A encodes a member of the WNT gene family of secreted signaling proteins. These proteins are involved in oncogenesis and several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT8A is specifically implicated in early embryonic development, particularly in the formation of the primitive streak and mesoderm induction.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | WNT8A overexpression activates canonical WNT/β-catenin signaling, promoting cell proliferation and tumorigenesis. | COSMIC, NCBI |
| Hepatocellular Carcinoma | Upregulation of WNT8A contributes to aberrant WNT signaling and tumor progression. | NCBI, COSMIC |
| Gastric Cancer | WNT8A expression is elevated and associated with poor prognosis via β-catenin pathway activation. | NCBI, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Placenta | 3.1 | Low |
| Kidney | 1.8 | Not detected |
| Liver | 0.9 | Not detected |
| Brain | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.3 | Not detected |
| HeLa | 0.1 | Not detected |
| K562 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.100C>T | missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression in several cancers suggests potential gain-of-function role.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region | • Wnt signaling pathway |
| • cell-cell signaling | • canonical Wnt signaling pathway |
| • embryonic development |
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Signaling by WNT (Reactome: R-HSA-195721)
Protein Summary
WNT8A is a secreted glycoprotein of approximately 40 kDa that binds to Frizzled receptors to activate the canonical WNT/β-catenin signaling cascade. It plays a critical role in early embryogenesis, particularly in mesoderm formation and axis specification. In adults, WNT8A expression is largely restricted to testis and placenta, but aberrant reactivation is observed in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WNT8A Knockout HEK293 Cell Line | EDJ-KQ1187 | Human | 7478 | Details Get a Quote |
| WNT8A Knockout HeLa Cell Line | EDJ-KQ54753 | Human | 7478 | Details Get a Quote |
| WNT8A Knockout A-549 Cell Line | EDJ-KQ63248 | Human | 7478 | Details Get a Quote |
| WNT8A Knockout HCT 116 Cell Line | EDJ-KQ71712 | Human | 7478 | Details Get a Quote |
