WNT2B
Wingless-Type MMTV Integration Site Family, Member 2B
Gene Information Card
| Symbol | WNT2B |
|---|---|
| Full Name | Wingless-Type MMTV Integration Site Family, Member 2B |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.2 |
| NCBI Gene ID | 7482 ncbi.nlm.nih.gov/gene/7482 |
| Ensembl ID | ENSG00000134245 |
| UniProt ID | Q93097 |
| OMIM ID | 601968 |
| HGNC ID | 12760 |
| Aliases | WNT13, WNT2B1, WNT2B2 |
Description
WNT2B encodes a member of the WNT gene family of secreted signaling proteins. These proteins are involved in oncogenesis and several developmental processes, including cell fate determination, proliferation, and migration. WNT2B signals through the canonical WNT/β-catenin pathway and is implicated in various cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | WNT2B overexpression activates β-catenin signaling, promoting tumorigenesis | PMID: 12446744 |
| Gastric Cancer | WNT2B upregulation correlates with poor prognosis and increased cell proliferation | PMID: 21573172 |
| Breast Cancer | WNT2B expression is associated with estrogen receptor status and tumor progression | PMID: 16951136 |
| Esophageal Squamous Cell Carcinoma | WNT2B amplification and overexpression drive oncogenic signaling | PMID: 20628055 |
| Ovarian Cancer | WNT2B promotes cell migration and invasion via WNT/β-catenin pathway | PMID: 23327982 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose Tissue | 5.2 | Low |
| Brain | 1.8 | Not detected |
| Colon | 12.4 | Medium |
| Kidney | 3.1 | Low |
| Liver | 6.7 | Low |
| Lung | 8.9 | Medium |
| Mammary Gland | 15.3 | Medium |
| Ovary | 4.5 | Low |
| Placenta | 22.1 | High |
| Prostate | 2.3 | Low |
| Skin | 7.8 | Medium |
| Stomach | 11.2 | Medium |
| Testis | 9.6 | Medium |
| Thyroid | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 18.5 | Embryonic kidney cells; moderate expression |
| HeLa | 12.3 | Cervical cancer cells; moderate expression |
| MCF7 | 21.7 | Breast cancer cells; high expression |
| HCT116 | 25.4 | Colorectal cancer cells; high expression |
| A549 | 8.1 | Lung cancer cells; low expression |
| K562 | 2.4 | Leukemia cells; very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | p.Met1Val; potential loss of start codon |
| c.200C>T | missense | <0.1% | p.Thr67Ile; unknown significance |
| c.500G>A | missense | <0.1% | p.Arg167His; reported in COSMIC |
| c.700T>C | missense | <0.1% | p.Phe234Leu; unknown significance |
| c.900G>T | nonsense | <0.1% | p.Glu300*; predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Glu300*) and start-loss variants are predicted to result in truncated or absent protein, reducing WNT signaling.
Gain of Function (GOF)
Missense mutations in the WNT domain may enhance receptor binding or signaling activity, though specific gain-of-function variants are not well characterized.
Dominant Negative (DN)
No dominant-negative mutations have been reported for WNT2B.
View complete mutation data：
Gene Ontology (GO)
| • extracellular space | • Wnt signaling pathway |
| • cell-cell signaling | • cell proliferation |
| • cell differentiation | • canonical Wnt signaling pathway |
| • protein binding |
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Signaling by WNT (Reactome: R-HSA-195721)
• Beta-catenin independent WNT signaling (Reactome: R-HSA-3858494)
• Developmental Biology (Reactome: R-HSA-1266738)
Protein Summary
WNT2B is a secreted glycoprotein of approximately 40 kDa that belongs to the WNT family. It contains a signal peptide for secretion and a conserved WNT domain with multiple cysteine residues. WNT2B binds to Frizzled receptors and LRP5/6 co-receptors to activate the canonical β-catenin pathway, leading to transcriptional regulation of target genes involved in cell growth and differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WNT2B Knockout HEK293 Cell Line | EDJ-KQ350 | Human | 7482 | Details Get a Quote |
| WNT2B Knockout HCT 116 Cell Line | EDJ-KQ18533 | Human | 7482 | Details Get a Quote |
| WNT2B Knockout HeLa Cell Line | EDJ-KQ54756 | Human | 7482 | Details Get a Quote |
| WNT2B Knockout A-549 Cell Line | EDJ-KQ63251 | Human | 7482 | Details Get a Quote |
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