WNT11 Gene - Wnt Family Member 11
A key signaling molecule in developmental processes and cancer biology
Gene Information Card
| Symbol | WNT11 |
|---|---|
| Full Name | Wnt family member 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.5 |
| NCBI Gene ID | 7481 ncbi.nlm.nih.gov/gene/7481 |
| Ensembl ID | ENSG00000085741 |
| UniProt ID | O96014 |
| OMIM ID | 603699 |
| HGNC ID | 12776 |
| Aliases | CTNNB1, WNT11B |
Description
WNT11 is a member of the WNT gene family, which encodes secreted signaling proteins involved in various developmental processes, including cell fate determination, cell polarity, and tissue morphogenesis. WNT11 signals through both canonical (β-catenin-dependent) and non-canonical (planar cell polarity) pathways, playing critical roles in embryogenesis and tissue homeostasis. Dysregulation of WNT11 has been implicated in several cancers and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | WNT11 promotes tumor progression via non-canonical signaling, enhancing cell migration and invasion. | COSMIC, PubMed |
| Developmental anomalies | Mutations in WNT11 can disrupt normal development, leading to skeletal and cardiac defects. | OMIM, PubMed |
| Osteoporosis | WNT11 regulates bone formation; altered expression may affect bone density. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Placenta | High | High |
| Kidney | Medium | Medium |
| Lung | Medium | Medium |
| Heart | Low | Low |
| Brain | Low | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC | High | Endothelial cells |
| MCF7 | Medium | Breast cancer cell line |
| A549 | Medium | Lung cancer cell line |
| HEK293 | Low | Embryonic kidney cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.346C>T (p.Arg116Cys) | Missense | Rare | Potential loss of function |
| c.512G>A (p.Arg171His) | Missense | Rare | Unknown |
| c.1000G>A (p.Val334Met) | Missense | Rare | Unknown |
Mutation functional classification
Loss of Function (LOF)
Some missense mutations may impair WNT11 secretion or receptor binding, reducing signaling activity.
Gain of Function (GOF)
Amplification or overexpression of WNT11 can enhance non-canonical signaling, promoting cell motility.
Dominant Negative (DN)
Truncating mutations could produce dominant-negative forms interfering with wild-type WNT11 function.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Planar cell polarity pathway
• Regulation of actin cytoskeleton
Protein Summary
WNT11 is a secreted glycoprotein that binds to frizzled receptors and activates non-canonical Wnt signaling pathways, particularly the planar cell polarity (PCP) pathway. It plays essential roles in embryonic development, including heart morphogenesis, kidney formation, and skeletal patterning. In adults, WNT11 is involved in tissue repair and stem cell maintenance. Aberrant WNT11 expression is associated with tumor progression and metastasis in various cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| WNT11 Knockout HEK293 Cell Line | EDJ-KQ1188 | Human | 7481 | Details Get a Quote |
| WNT11 Knockout HeLa Cell Line | EDJ-KQ54755 | Human | 7481 | Details Get a Quote |
| WNT11 Knockout A-549 Cell Line | EDJ-KQ63250 | Human | 7481 | Details Get a Quote |
| WNT11 Knockout HCT 116 Cell Line | EDJ-KQ71714 | Human | 7481 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
