VNN2 (Vanin 2)
GPI-anchored pantetheinase involved in oxidative stress and inflammation
Gene Information Card
| Symbol | VNN2 |
|---|---|
| Full Name | Vanin 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 6q23.2 |
| NCBI Gene ID | 8875 ncbi.nlm.nih.gov/gene/8875 |
| Ensembl ID | ENSG00000112237 |
| UniProt ID | O95498 |
| OMIM ID | 606592 |
| HGNC ID | 12678 |
| Aliases | GPI-80, FOAP-4, pantetheinase 2 |
Description
VNN2 encodes vanin 2, a glycosylphosphatidylinositol (GPI)-anchored pantetheinase that hydrolyzes pantetheine to pantothenic acid (vitamin B5) and cysteamine. The enzyme is involved in oxidative stress response, inflammatory processes, and leukocyte adhesion. VNN2 is expressed on the surface of neutrophils and monocytes and plays a role in cell migration and immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory bowel disease | Altered pantetheinase activity may modulate oxidative stress and inflammation in gut mucosa | PMID: 20555362 |
| Rheumatoid arthritis | Elevated VNN2 expression in synovial fluid neutrophils contributes to joint inflammation | PMID: 21880762 |
| Colorectal cancer | VNN2 overexpression linked to tumor progression and poor prognosis | PMID: 29351288 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lung | 8.3 | Low |
| Spleen | 7.1 | Low |
| Small intestine | 6.9 | Low |
| Blood | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (promyeloblast) | 15.2 | High expression after differentiation |
| THP-1 (monocyte) | 10.8 | Moderate expression |
| K-562 (erythroleukemia) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Unknown functional impact |
| c.421C>T (p.Arg141Trp) | Missense | <0.01% | Potential loss of pantetheinase activity |
Mutation functional classification
Loss of Function (LOF)
Missense variants in the catalytic domain may reduce pantetheinase activity, impairing cysteamine production and antioxidant capacity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Pantothenate and CoA biosynthesis (Reactome: R-HSA-196783)
• Vitamin B5 metabolism (KEGG: hsa00770)
Protein Summary
Vanin 2 is a 513-amino acid GPI-anchored protein with pantetheinase activity. It is primarily expressed on myeloid cells and cleaves pantetheine to generate cysteamine, a potent antioxidant. The protein is involved in leukocyte adhesion, migration, and inflammatory signaling. Its expression is upregulated in various inflammatory conditions and cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VNN2 Knockout HEK293 Cell Line | EDJ-KQ6388 | Human | 8875 | Details Get a Quote |
| VNN2 Knockout HeLa Cell Line | EDJ-KQ55026 | Human | 8875 | Details Get a Quote |
| VNN2 Knockout A-549 Cell Line | EDJ-KQ63512 | Human | 8875 | Details Get a Quote |
| VNN2 Knockout HCT 116 Cell Line | EDJ-KQ71978 | Human | 8875 | Details Get a Quote |
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