VCAN (Versican) Gene
Extracellular matrix proteoglycan involved in cell adhesion, migration, and proliferation
Gene Information Card
| Symbol | VCAN |
|---|---|
| Full Name | Versican |
| Gene Type | Protein coding |
| Chromosomal Location | 5q14.3 |
| NCBI Gene ID | 1462 ncbi.nlm.nih.gov/gene/1462 |
| Ensembl ID | ENSG00000038427 |
| UniProt ID | P13611 |
| OMIM ID | 118661 |
| HGNC ID | 12665 |
| Aliases | CSPG2, PG-M, WGN, WGN1 |
Description
The VCAN gene encodes versican, a large chondroitin sulfate proteoglycan of the extracellular matrix. Versican plays key roles in cell adhesion, proliferation, migration, and tissue morphogenesis. It is involved in inflammation, cancer progression, and cardiovascular diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Wagner syndrome | Extracellular matrix dysregulation due to VCAN mutations | OMIM #143200 |
| Vitreoretinopathy, neovascular inflammatory | Altered versican expression leading to abnormal angiogenesis | OMIM #193235 |
| Aortic aneurysm, familial thoracic | Versican deficiency affecting aortic wall integrity | OMIM #617439 |
| Cancer (various) | Overexpression of versican promotes tumor invasion and metastasis | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Lung | 8.3 | Low |
| Brain | 6.1 | Low |
| Liver | 2.4 | Not detected |
| Kidney | 9.7 | Low |
| Skeletal muscle | 4.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Medium |
| A549 | 22.1 | High |
| MCF7 | 8.9 | Low |
| HepG2 | 3.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.4004G>A (p.Arg1335Gln) | Missense | <0.01% | Alters GAG attachment site |
| c.9265C>T (p.Arg3089*) | Nonsense | <0.01% | Premature truncation, loss of function |
| c.1157_1158del (p.Leu386fs) | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated versican, impairing extracellular matrix integrity.
Gain of Function (GOF)
Not well documented; overexpression in cancer may act as gain-of-function.
Dominant Negative (DN)
Missense mutations in GAG attachment regions may disrupt versican interactions.
View complete mutation data：
Gene Ontology (GO)
Pathways
• ECM-receptor interaction (KEGG hsa04512)
• Proteoglycans in cancer (KEGG hsa05205)
• PI3K-Akt signaling pathway (KEGG hsa04151)
Protein Summary
Versican is a large chondroitin sulfate proteoglycan that binds hyaluronan and other ECM components. It modulates cell adhesion, migration, and proliferation through interactions with CD44, integrins, and growth factors. Alternative splicing generates four isoforms (V0, V1, V2, V3) with distinct functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VCAN Knockout HEK293 Cell Line | EDJ-KQ4368 | Human | 1462 | Details Get a Quote |
| VCAN Knockout HCT 116 Cell Line | EDJ-KQ25596 | Human | 1462 | Details Get a Quote |
| VCAN Knockout A-549 Cell Line | EDJ-KQ26874 | Human | 1462 | Details Get a Quote |
| VCAN Knockout HeLa Cell Line | EDJ-KQ53013 | Human | 1462 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
