VASP (Vasodilator-Stimulated Phosphoprotein)
Actin cytoskeleton regulator and cell adhesion modulator
Gene Information Card
| Symbol | VASP |
|---|---|
| Full Name | Vasodilator-stimulated phosphoprotein |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.32 |
| NCBI Gene ID | 7408 ncbi.nlm.nih.gov/gene/7408 |
| Ensembl ID | ENSG00000100263 |
| UniProt ID | P50552 |
| OMIM ID | 601617 |
| HGNC ID | 12652 |
| Aliases | VASP |
Description
VASP (vasodilator-stimulated phosphoprotein) is a member of the Ena/VASP family of actin-associated proteins. It regulates actin filament dynamics, cell adhesion, and cell migration. VASP localizes to focal adhesions, lamellipodia, and filopodia, and is involved in platelet aggregation, endothelial barrier function, and cancer cell invasion. Its activity is modulated by phosphorylation via cAMP- and cGMP-dependent protein kinases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered VASP expression and phosphorylation affect cell migration and invasion; overexpression correlates with poor prognosis. | COSMIC; PMID: 21573173 |
| Breast cancer | VASP overexpression promotes metastasis through enhanced actin dynamics and focal adhesion turnover. | COSMIC; PMID: 23431263 |
| Cardiovascular disease | VASP phosphorylation status is a marker of platelet inhibition; dysregulation linked to thrombosis and atherosclerosis. | ClinVar; PMID: 15598816 |
| Inflammatory bowel disease | VASP expression changes in intestinal epithelium may contribute to barrier dysfunction. | OMIM; PMID: 20628086 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Blood | 12.2 | Medium |
| Heart | 8.5 | Medium |
| Lung | 10.1 | Medium |
| Liver | 6.3 | Low |
| Kidney | 9.8 | Medium |
| Brain | 7.4 | Low |
| Colon | 11.5 | Medium |
| Breast | 9.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.3 | Cervical cancer cell line |
| MCF7 | 11.8 | Breast cancer cell line |
| A549 | 10.5 | Lung cancer cell line |
| HCT116 | 13.1 | Colorectal cancer cell line |
| HEK293 | 9.2 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Likely benign; no functional data |
| c.103C>T | Missense | <0.01% | Unknown significance |
| c.214G>A | Missense | <0.01% | Unknown significance |
| c.340C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.340C>T) are predicted to cause premature truncation and loss of actin-binding and regulatory functions.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in VASP.
Dominant Negative (DN)
No dominant-negative mutations described for VASP.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • actin filament binding |
| • cell adhesion | • cell migration |
| • focal adhesion assembly | • lamellipodium assembly |
| • filopodium assembly | • platelet aggregation |
| • signal transduction | • protein phosphorylation |
Pathways
• cGMP-PKG signaling pathway
• cAMP-PKA signaling pathway
• Focal adhesion
• Regulation of actin cytoskeleton
• Platelet activation
Protein Summary
VASP is a 380-amino-acid protein (UniProt P50552) that contains an N-terminal Ena/VASP homology 1 (EVH1) domain, a central proline-rich region, and a C-terminal EVH2 domain. The EVH1 domain mediates binding to focal adhesion proteins such as zyxin and vinculin. The EVH2 domain binds actin and promotes filament elongation. Phosphorylation at Ser157, Ser239, and Thr278 by PKA and PKG regulates its localization and activity. VASP is widely expressed and plays key roles in cell motility, adhesion, and platelet function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VASP Knockout HEK293 Cell Line | EDJ-KQ760 | Human | 7408 | Details Get a Quote |
| VASP Knockout A-549 Cell Line | EDJ-KQ20776 | Human | 7408 | Details Get a Quote |
| VASP Knockout HCT 116 Cell Line | EDJ-KQ20778 | Human | 7408 | Details Get a Quote |
| VASP Knockout HeLa Cell Line | EDJ-KQ20779 | Human | 7408 | Details Get a Quote |
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