URGCP-MRPS24 Gene: Function, Expression, and Disease Associations | Biomedical SEO

URGCP-MRPS24 is a read-through gene located on chromosome 7q36.1, formed by the natural fusion of the upstream URGCP (upregulator of cell proliferation) and downstream MRPS24 (mitochondrial ribosomal protein S24) genes. This read-through transcript is predicted to be a candidate for nonsense-mediated decay (NMD), meaning it may not produce a functional protein. The gene is listed in the HGNC database as a read-through locus, and its existence is supported by transcript evidence in NCBI and Ensembl. However, no protein product has been annotated in UniProt, and no disease associations have been curated in OMIM or ClinVar. The gene's expression is inferred from RNA-seq data, but its functional significance remains unclear.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

No protein product has been annotated for URGCP-MRPS24. The read-through transcript is predicted to undergo nonsense-mediated decay, and thus it is unlikely to be translated into a stable protein. The individual genes URGCP and MRPS24 encode distinct proteins: URGCP is involved in cell proliferation, while MRPS24 is a component of the mitochondrial small ribosomal subunit. However, the read-through transcript itself does not have a known protein function.