UNC5C (Unc-5 Netrin Receptor C)
Netrin receptor involved in axon guidance and tumor suppression
Gene Information Card
| Symbol | UNC5C |
|---|---|
| Full Name | Unc-5 Netrin Receptor C |
| Gene Type | protein-coding |
| Chromosomal Location | 4q22.3 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000182168 |
| UniProt ID | O95185 |
| OMIM ID | 602610 |
| HGNC ID | 12569 |
| Aliases | UNC5H3, UNC5C1 |
Description
UNC5C encodes a member of the UNC-5 family of netrin receptors, which are transmembrane proteins that mediate axon guidance and cell migration in response to netrin-1. In the absence of netrin-1, UNC5C can induce apoptosis, acting as a dependence receptor. Loss of UNC5C expression is associated with colorectal cancer and other malignancies, suggesting a tumor suppressor role.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Loss of UNC5C expression via promoter methylation leads to reduced apoptosis and increased tumor progression. | PMID: 12446744, COSMIC |
| Breast Cancer | UNC5C downregulation correlates with poor prognosis and metastasis. | PMID: 21804531 |
| Pancreatic Cancer | Epigenetic silencing of UNC5C contributes to tumor growth. | PMID: 19029981 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Colon | 8.3 | Low |
| Breast | 6.1 | Low |
| Pancreas | 4.2 | Low |
| Lung | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HCT116 (Colorectal) | 2.1 | Low expression; promoter hypermethylation common |
| MCF7 (Breast) | 1.5 | Reduced expression compared to normal |
| PANC-1 (Pancreatic) | 0.9 | Very low; silenced by methylation |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1456C>T (p.Arg486*) | Nonsense | <1% | Loss of function; truncation |
| c.2023G>A (p.Gly675Arg) | Missense | <1% | Unknown significance |
| Promoter methylation | Epigenetic | Variable | Silencing; common in colorectal cancer |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations and promoter methylation lead to loss of UNC5C expression or function, impairing apoptosis and promoting tumorigenesis.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • netrin receptor activity (GO:0005042) | • axon guidance (GO:0007411) |
| • apoptotic process (GO:0006915) | • signal transduction (GO:0007165) |
| • cell migration (GO:0016477) |
Pathways
• Netrin-1 signaling (Reactome: R-HSA-373752)
• Apoptosis (KEGG: hsa04210)
• Axon guidance (KEGG: hsa04360)
Protein Summary
UNC5C is a transmembrane netrin receptor of the immunoglobulin superfamily. It contains two immunoglobulin-like domains and two thrombospondin type-1 domains in the extracellular region, and a death domain in the intracellular region. In the absence of netrin-1, UNC5C recruits caspase activators to induce apoptosis. It is widely expressed in neural tissues and at lower levels in epithelial tissues. Loss of UNC5C function is implicated in cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UNC5C Knockout HEK293 Cell Line | EDJ-KQ6308 | Human | 8633 | Details Get a Quote |
| UNC5CL Knockout HEK293 Cell Line | EDJ-KQ8274 | Human | 222643 | Details Get a Quote |
| UNC5CL Knockout A-549 Cell Line | EDJ-KQ35476 | Human | 222643 | Details Get a Quote |
| UNC5C Knockout HeLa Cell Line | EDJ-KQ54961 | Human | 8633 | Details Get a Quote |
| UNC5CL Knockout HeLa Cell Line | EDJ-KQ59195 | Human | 222643 | Details Get a Quote |
| UNC5C Knockout A-549 Cell Line | EDJ-KQ63444 | Human | 8633 | Details Get a Quote |
| UNC5C Knockout HCT 116 Cell Line | EDJ-KQ71912 | Human | 8633 | Details Get a Quote |
| UNC5CL Knockout HCT 116 Cell Line | EDJ-KQ76050 | Human | 222643 | Details Get a Quote |
