UGT3A2
UDP Glycosyltransferase 3 Family Member A2
Gene Information Card
| Symbol | UGT3A2 |
|---|---|
| Full Name | UDP Glycosyltransferase 3 Family Member A2 |
| Gene Type | protein-coding |
| Chromosomal Location | 5p13.2 |
| NCBI Gene ID | 167127 ncbi.nlm.nih.gov/gene/167127 |
| Ensembl ID | ENSG00000145675 |
| UniProt ID | Q6UWM9 |
| OMIM ID | 616392 |
| HGNC ID | 26911 |
| Aliases | UDPGT3A2, UGT3A2 |
Description
UGT3A2 encodes a member of the UDP-glycosyltransferase 3 family. This enzyme catalyzes the transfer of sugar moieties from UDP-sugars to acceptor molecules, playing a role in the metabolism of endogenous and exogenous compounds. The protein is involved in glycosylation processes and may contribute to detoxification pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 0.0 | Not detected |
| Kidney | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
| Thyroid | 0.0 | Not detected |
| Adrenal | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar or COSMIC | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • UDP-glycosyltransferase activity (GO:0008194) | • hexosyltransferase activity (GO:0016758) |
| • Golgi apparatus (GO:0005794) | • endoplasmic reticulum (GO:0005783) |
Pathways
• Metabolism of xenobiotics by cytochrome P450 (indirect via glycosylation)
Protein Summary
UGT3A2 is a 523-amino acid protein with a predicted molecular weight of approximately 59 kDa. It contains a conserved UDP-glycosyltransferase domain and is localized to the endoplasmic reticulum and Golgi apparatus. The enzyme transfers sugar residues to small lipophilic molecules, potentially modulating their activity or facilitating elimination.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UGT3A2 Knockout HEK293 Cell Line | EDJ-KQ16025 | Human | 167127 | Details Get a Quote |
| UGT3A2 Knockout HeLa Cell Line | EDJ-KQ58901 | Human | 167127 | Details Get a Quote |
| UGT3A2 Knockout A-549 Cell Line | EDJ-KQ67390 | Human | 167127 | Details Get a Quote |
| UGT3A2 Knockout HCT 116 Cell Line | EDJ-KQ75783 | Human | 167127 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
