TSPAN10
Tetraspanin 10: A Cell Surface Protein with Roles in Cell Adhesion and Signaling
Gene Information Card
| Symbol | TSPAN10 |
|---|---|
| Full Name | Tetraspanin 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 83882 ncbi.nlm.nih.gov/gene/83882 |
| Ensembl ID | ENSG00000182612 |
| UniProt ID | Q9H1Z9 |
| OMIM ID | 613218 |
| HGNC ID | 30788 |
| Aliases | OCSP, TSPAN-10, tetraspanin-10 |
Description
TSPAN10 (tetraspanin 10) is a protein-coding gene located on chromosome 17q25.3. It encodes a member of the tetraspanin family, which are transmembrane proteins involved in cell adhesion, migration, and signal transduction. TSPAN10 is expressed in various tissues and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression may affect cell adhesion and signaling pathways | Expression studies in tumor tissues |
| Retinal degeneration | Potential role in photoreceptor cell function | Association studies in animal models |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 3.4 | Not detected |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | Moderate expression |
| HeLa | 10.1 | Low expression |
| K562 | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200C>T (p.Pro67Leu) | Missense | <0.01% | Unknown functional impact |
| c.345G>A (p.Val115Ile) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion | • signal transduction |
| • plasma membrane | • integral component of membrane |
Pathways
• Tetraspanin-enriched microdomains
• Integrin signaling
Protein Summary
Tetraspanin 10 is a 4-transmembrane domain protein that localizes to the plasma membrane. It participates in cell adhesion and signaling by organizing multi-protein complexes. Its expression is regulated in development and disease.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPAN10 Knockout HEK293 Cell Line | EDJ-KQ9919 | Human | 83882 | Details Get a Quote |
| TSPAN10 Knockout A-549 Cell Line | EDJ-KQ36821 | Human | 83882 | Details Get a Quote |
| TSPAN10 Knockout HCT 116 Cell Line | EDJ-KQ36822 | Human | 83882 | Details Get a Quote |
| TSPAN10 Knockout HeLa Cell Line | EDJ-KQ36823 | Human | 83882 | Details Get a Quote |
