TRPM7 Gene - Ion Channel and Kinase in Magnesium Homeostasis and Disease

TRPM7 encodes a bifunctional protein combining a transient receptor potential (TRP) cation channel with a C-terminal alpha-kinase domain. The channel is permeable to divalent cations, especially Mg2+, Ca2+, and Zn2+, and is essential for cellular magnesium homeostasis. The kinase domain autophosphorylates and phosphorylates substrates such as annexin A1, regulating cell adhesion, migration, and proliferation. TRPM7 is ubiquitously expressed and plays roles in embryonic development, immune function, and neuronal survival. Dysregulation is linked to cancer metastasis, neurodegenerative disorders, and cardiovascular diseases.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• hsa04750: Inflammatory mediator regulation of TRP channels

• hsa04020: Calcium signaling pathway

• hsa04151: PI3K-Akt signaling pathway

• hsa04810: Regulation of actin cytoskeleton

• hsa05200: Pathways in cancer

TRPM7 is a 1863-amino acid protein with an N-terminal TRP channel domain (six transmembrane segments) and a C-terminal alpha-kinase domain. The channel forms homotetramers permeable to Mg2+, Ca2+, and Zn2+. The kinase domain autophosphorylates and phosphorylates substrates like annexin A1, myosin IIA, and PLCγ2, linking ion flux to cytoskeletal dynamics and cell signaling. TRPM7 is ubiquitously expressed and localizes to the plasma membrane and intracellular vesicles. Its dual function integrates ion homeostasis with kinase-mediated signaling, critical for cell migration, proliferation, and survival.