TRIP6: Thyroid Hormone Receptor Interactor 6 – Gene Overview
Comprehensive biomedical profile of TRIP6, a Zyxin family member involved in transcriptional regulation, cell migration, and cancer signaling.
Gene Information Card
| Symbol | TRIP6 |
|---|---|
| Full Name | Thyroid Hormone Receptor Interactor 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 7q22.1 |
| NCBI Gene ID | 7205 ncbi.nlm.nih.gov/gene/7205 |
| Ensembl ID | ENSG00000106031 |
| UniProt ID | Q15654 |
| OMIM ID | 602529 |
| HGNC ID | 12311 |
| Aliases | ZRP-1, OIP1, TRIP-6 |
Description
TRIP6 (Thyroid Hormone Receptor Interactor 6) is a protein-coding gene belonging to the zyxin family of LIM domain-containing proteins. It functions as a transcriptional coactivator for thyroid hormone receptor and other nuclear receptors, and plays a role in cell adhesion, migration, and signal transduction. TRIP6 localizes to focal adhesions and shuttles between the cytoplasm and nucleus to modulate gene expression. Overexpression and mutations have been implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | TRIP6 overexpression promotes cell migration and invasion via focal adhesion kinase (FAK) signaling. | PMID: 20628086 |
| Colorectal cancer | TRIP6 upregulation correlates with tumor progression and poor prognosis; enhances Wnt/β-catenin signaling. | PMID: 25242043 |
| Glioma | TRIP6 expression is elevated and associated with increased cell proliferation and migration. | PMID: 29367642 |
| Ovarian cancer | TRIP6 contributes to metastatic potential through regulation of actin cytoskeleton dynamics. | PMID: 23542344 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 17.3 | Medium |
| Breast | 12.8 | Medium |
| Colon | 15.1 | Medium |
| Ovary | 9.5 | Low |
| Brain | 6.2 | Low |
| Liver | 8.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 14.5 | Moderate expression |
| HCT116 (colorectal cancer) | 18.2 | High expression |
| A549 (lung cancer) | 16.0 | Moderate expression |
| U87MG (glioma) | 11.3 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.1% | Unknown functional effect; reported in COSMIC |
| c.1246G>A (p.Glu416Lys) | Missense | <0.1% | Located in LIM domain; potential impact on protein-protein interactions |
| c.148_149insA (p.Thr50Asnfs*12) | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.148_149insA) are predicted to cause premature truncation and loss of LIM domains, impairing transcriptional coactivator function.
Gain of Function (GOF)
Missense mutations in the LIM domains may enhance protein stability or alter binding partners, potentially contributing to oncogenic signaling.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for TRIP6.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Focal adhesion (KEGG: hsa04510)
• Wnt signaling pathway (KEGG: hsa04310)
• Thyroid hormone signaling pathway (KEGG: hsa04919)
• Regulation of actin cytoskeleton (KEGG: hsa04810)
Protein Summary
TRIP6 encodes a 476-amino acid protein with three C-terminal LIM domains and a proline-rich N-terminal region. It localizes to focal adhesions and interacts with thyroid hormone receptor, FAK, and other signaling molecules. TRIP6 shuttles to the nucleus to act as a transcriptional coactivator. Its expression is elevated in several cancers, where it promotes cell migration, invasion, and proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIP6 Knockout HEK293 Cell Line | EDJ-KQ5963 | Human | 7205 | Details Get a Quote |
| TRIP6 Knockout A-549 Cell Line | EDJ-KQ29531 | Human | 7205 | Details Get a Quote |
| TRIP6 Knockout HCT 116 Cell Line | EDJ-KQ29532 | Human | 7205 | Details Get a Quote |
| TRIP6 Knockout HeLa Cell Line | EDJ-KQ29533 | Human | 7205 | Details Get a Quote |
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