TRIM69: Tripartite Motif Containing 69
A RING finger protein involved in antiviral immunity and potential tumor suppression
Gene Information Card
| Symbol | TRIM69 |
|---|---|
| Full Name | Tripartite Motif Containing 69 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q21.1 |
| NCBI Gene ID | 140691 ncbi.nlm.nih.gov/gene/140691 |
| Ensembl ID | ENSG00000185811 |
| UniProt ID | Q86WT6 |
| OMIM ID | 618908 |
| HGNC ID | 26943 |
| Aliases | RNF69, HSD-39, TRIM69A, TRIM69B |
Description
TRIM69 (Tripartite Motif Containing 69) is a protein-coding gene that belongs to the tripartite motif (TRIM) family. The encoded protein contains a RING finger domain, B-box type 1 and type 2 domains, and a coiled-coil region. TRIM69 functions as an E3 ubiquitin ligase and plays a role in antiviral innate immunity by restricting viral replication, particularly against flaviviruses such as dengue virus. It also has been implicated in cell cycle regulation and may act as a tumor suppressor in certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Dengue virus infection | TRIM69 restricts dengue virus replication by ubiquitinating viral NS3 protein | PMID: 29386363 |
| Hepatocellular carcinoma | Downregulation of TRIM69 correlates with poor prognosis; loss promotes proliferation and metastasis | PMID: 31827240 |
| Breast cancer | Reduced TRIM69 expression associated with aggressive tumor features and shorter survival | PMID: 32644122 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lung | 6.1 | Low |
| Liver | 4.7 | Low |
| Breast | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 5.2 | Hepatocellular carcinoma cell line |
| MCF7 | 4.1 | Breast cancer cell line |
| A549 | 3.8 | Lung carcinoma cell line |
| HEK293 | 2.9 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional effect |
| c.1012G>A (p.Gly338Arg) | Missense | <0.01% | Unknown functional effect |
| c.1345_1346insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.1345_1346insA) are predicted to cause premature truncation and loss of E3 ubiquitin ligase activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported for TRIM69.
Dominant Negative (DN)
No dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• RIG-I-like receptor signaling pathway (KEGG: hsa04622)
• Antiviral mechanism by TRIM proteins (Reactome: R-HSA-936440)
Protein Summary
TRIM69 is a 497-amino acid protein with a molecular weight of approximately 56 kDa. It contains an N-terminal RING finger domain (residues 15-55) that confers E3 ubiquitin ligase activity, followed by two B-box domains (B-box1: 91-133; B-box2: 147-189) and a coiled-coil region (residues 200-250). The protein localizes to the cytoplasm and is involved in ubiquitination of viral proteins, thereby restricting viral replication. TRIM69 also interacts with cellular proteins to modulate cell cycle progression and apoptosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM69 Knockout HEK293 Cell Line | EDJ-KQ9795 | Human | 140691 | Details Get a Quote |
| TRIM69 Knockout A-549 Cell Line | EDJ-KQ36635 | Human | 140691 | Details Get a Quote |
| TRIM69 Knockout HCT 116 Cell Line | EDJ-KQ36636 | Human | 140691 | Details Get a Quote |
| TRIM69 Knockout HeLa Cell Line | EDJ-KQ36637 | Human | 140691 | Details Get a Quote |
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