TRIM68: Tripartite Motif Containing 68
A RING-type E3 ubiquitin ligase involved in immune regulation and cancer
Gene Information Card
| Symbol | TRIM68 |
|---|---|
| Full Name | Tripartite Motif Containing 68 |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 55128 ncbi.nlm.nih.gov/gene/55128 |
| Ensembl ID | ENSG00000110367 |
| UniProt ID | Q6ZUT3 |
| OMIM ID | 616248 |
| HGNC ID | 26938 |
| Aliases | RNF137, SS-56, SSA-like |
Description
TRIM68 encodes a member of the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc fingers, and a coiled-coil region. The protein functions as an E3 ubiquitin ligase, mediating ubiquitination and degradation of target proteins. TRIM68 is involved in innate immune signaling, particularly in the regulation of type I interferon responses, and has been implicated in autoimmune diseases and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic lupus erythematosus | Autoantibody target; TRIM68 is recognized by sera from SLE patients, suggesting a role in autoimmunity. | PMID: 15689452 |
| Breast cancer | Overexpression in breast tumors; may promote cell proliferation via ubiquitination of tumor suppressors. | PMID: 21734254 |
| Prostate cancer | Upregulated in prostate cancer; associated with androgen receptor signaling. | PMID: 23251476 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Low |
| Testis | 6.4 | Low |
| Lung | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | High expression |
| HeLa | 9.7 | Medium expression |
| MCF7 | 7.2 | Medium expression |
| K562 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional impact |
| c.457G>A (p.Glu153Lys) | Missense | <0.01% | Predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TRIM68.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• RIG-I-like receptor signaling pathway (Reactome: R-HSA-168928)
• Ubiquitin-mediated proteolysis (KEGG: hsa04120)
• Interferon alpha/beta signaling (Reactome: R-HSA-909733)
Protein Summary
TRIM68 is a 493-amino acid protein with a molecular weight of approximately 56 kDa. It contains an N-terminal RING finger domain (required for E3 ligase activity), two B-box zinc fingers, a coiled-coil region, and a C-terminal SPRY domain. The protein localizes to the cytoplasm and nucleus. Through its E3 ubiquitin ligase activity, TRIM68 targets substrates such as IRF3 and IRF7 for ubiquitination, modulating antiviral immune responses. Overexpression in certain cancers suggests a role in oncogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM68 Knockout HEK293 Cell Line | EDJ-KQ15929 | Human | 55128 | Details Get a Quote |
| TRIM68 Knockout A-549 Cell Line | EDJ-KQ46936 | Human | 55128 | Details Get a Quote |
| TRIM68 Knockout HCT 116 Cell Line | EDJ-KQ46937 | Human | 55128 | Details Get a Quote |
| TRIM68 Knockout HeLa Cell Line | EDJ-KQ46938 | Human | 55128 | Details Get a Quote |
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