TRIM67: Tripartite Motif Containing 67
A member of the TRIM family involved in neurodevelopment and potential tumor suppression.
Gene Information Card
| Symbol | TRIM67 |
|---|---|
| Full Name | Tripartite Motif Containing 67 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q42.2 |
| NCBI Gene ID | 440730 ncbi.nlm.nih.gov/gene/440730 |
| Ensembl ID | ENSG00000143149 |
| UniProt ID | Q5TCG1 |
| OMIM ID | 610584 |
| HGNC ID | 24088 |
| Aliases | TRIM67, TNL-1, tripartite motif-containing 67 |
Description
TRIM67 (Tripartite Motif Containing 67) is a protein-coding gene belonging to the tripartite motif (TRIM) family. The encoded protein contains a RING finger domain, B-box zinc finger, and coiled-coil region, characteristic of TRIM proteins. TRIM67 is implicated in neurodevelopment, particularly in axon guidance and neuronal migration, and may function as a tumor suppressor in certain cancers. It is also involved in ubiquitination and cellular signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neurodevelopmental disorders | Altered TRIM67 expression may disrupt neuronal migration and axon guidance, contributing to developmental phenotypes. | PMID: 25664889 |
| Colorectal cancer | TRIM67 is downregulated in colorectal cancer; loss of function may promote tumor growth. | PMID: 31073040 |
| Breast cancer | Reduced TRIM67 expression correlates with poor prognosis; potential tumor suppressor role. | PMID: 31570863 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Low |
| Lung | 4.1 | Low |
| Colon | 3.2 | Low |
| Breast | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | Neuronal model |
| HEK293 (embryonic kidney) | 6.7 | Common cell line |
| HCT116 (colorectal carcinoma) | 2.1 | Low expression |
| MCF7 (breast cancer) | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338*) | Nonsense | Rare | Loss of function |
| c.1456G>A (p.Gly486Ser) | Missense | Rare | Unknown significance |
| c.789_790insA | Frameshift | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in TRIM67 are predicted to cause loss of function, potentially contributing to neurodevelopmental phenotypes and cancer.
Gain of Function (GOF)
No gain-of-function mutations have been reported for TRIM67.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for TRIM67.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • zinc ion binding (GO:0008270) |
| • metal ion binding (GO:0046872) | • ubiquitin protein ligase activity (GO:0061630) |
| • nervous system development (GO:0007399) |
Pathways
• Ubiquitin-proteasome pathway
• p53 signaling pathway (potential)
Protein Summary
The TRIM67 protein is a 674-amino acid member of the TRIM family, characterized by an N-terminal RING finger domain, two B-box zinc fingers, and a coiled-coil region. It localizes to the cytoplasm and is involved in ubiquitination and protein degradation. TRIM67 plays a role in neuronal development, including axon guidance and dendritic arborization. In cancer, reduced expression suggests a tumor suppressor function, possibly through modulation of p53 or other signaling pathways.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM67 Knockout HEK293 Cell Line | EDJ-KQ15928 | Human | 440730 | Details Get a Quote |
| TRIM67 Knockout HeLa Cell Line | EDJ-KQ60404 | Human | 440730 | Details Get a Quote |
| TRIM67 Knockout A-549 Cell Line | EDJ-KQ68872 | Human | 440730 | Details Get a Quote |
| TRIM67 Knockout HCT 116 Cell Line | EDJ-KQ77234 | Human | 440730 | Details Get a Quote |
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