TRIM66 Gene: Tripartite Motif Containing 66
Transcriptional repressor involved in chromatin remodeling and cancer
Gene Information Card
| Symbol | TRIM66 |
|---|---|
| Full Name | Tripartite Motif Containing 66 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 55110 ncbi.nlm.nih.gov/gene/55110 |
| Ensembl ID | ENSG00000166165 |
| UniProt ID | Q96I34 |
| OMIM ID | 611634 |
| HGNC ID | 19014 |
| Aliases | TIF1-delta, TIF1D, FLJ11273 |
Description
TRIM66 (Tripartite Motif Containing 66) encodes a member of the tripartite motif (TRIM) family, also known as TIF1-delta. The protein contains a RING finger domain, B-box zinc finger, and coiled-coil region, and functions as a transcriptional repressor by recruiting chromatin remodeling complexes. It is involved in regulating gene expression during development and has been implicated in cancer progression, particularly through epigenetic silencing of tumor suppressor genes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression of TRIM66 promotes tumor growth by repressing tumor suppressor genes via histone modification | COSMIC, PubMed (PMID: 25605274) |
| Lung cancer | TRIM66 upregulation correlates with poor prognosis and promotes cell proliferation | ClinVar, PubMed (PMID: 29367642) |
| Breast cancer | TRIM66 acts as an oncogene by enhancing cell migration and invasion | PubMed (PMID: 30348671) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 3.2 | Low |
| Lung | 2.1 | Low |
| Breast | 1.8 | Low |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 4.3 | Cervical cancer cell line |
| A549 | 6.7 | Lung cancer cell line |
| MCF7 | 5.1 | Breast cancer cell line |
| HEK293 | 2.0 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; truncation of protein |
| c.567G>A (p.Met189Ile) | Missense | <0.1% | Unknown; possibly benign |
| c.890_891insA (p.Glu297fs) | Frameshift | <0.1% | Loss of function; predicted protein truncation |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in TRIM66 lead to truncated proteins lacking functional domains, impairing transcriptional repression activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in TRIM66.
Dominant Negative (DN)
No evidence of dominant-negative effects for TRIM66 mutations.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Chromatin remodeling (via histone deacetylase recruitment)
• Transcriptional repression by TRIM proteins
Protein Summary
TRIM66 is a 1,058-amino acid protein belonging to the TIF1 subfamily of TRIM proteins. It contains an N-terminal RING finger domain, two B-box zinc fingers, and a coiled-coil region, followed by a C-terminal PHD finger and bromodomain. The protein localizes to the nucleus and acts as a transcriptional corepressor by recruiting histone deacetylases and other chromatin modifiers. TRIM66 is highly expressed in testis and is implicated in spermatogenesis and cancer cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM66 Knockout HEK293 Cell Line | EDJ-KQ6134 | Human | 9866 | Details Get a Quote |
| TRIM66 Knockout A-549 Cell Line | EDJ-KQ31267 | Human | 9866 | Details Get a Quote |
| TRIM66 Knockout HCT 116 Cell Line | EDJ-KQ31268 | Human | 9866 | Details Get a Quote |
| TRIM66 Knockout HeLa Cell Line | EDJ-KQ31269 | Human | 9866 | Details Get a Quote |
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